MHC. Histocompatibility Ags 1-Minor Histocompatibility Complex HLA 2-Major Histocompatiblity Complex H-2. Major Histocompatibility Complex (MHC). What is MHC? HLA H-2 Minor histocompatibility antigens.
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1-Minor Histocompatibility Complex
2-Major Histocompatiblity Complex H-2
Cytotoxic T lymphocyte (CTL) generation
8-10 residue,greatest variability,anchor site
2. Immunoglobulin-like region = highly conserved α3 domain that homologus to Ig domain and non-covalently bound to beta2 Mic- site to which CD8 on T cell binds
residues lining groove most polymorphic
peptide in groove 8-10 amino acids long
specific amino acid on peptide required for “anchor site” in grooveStructure of Class I MHC Peptide-binding Region
Peptide-binding region – a groove formed from the α1 and β1 domains of the α and β chains – site of polymorphism
Immunoglobulin-like region – conserved α2 and β2 domains – β2 is site to which CD4 on T cell bindsStructure of Class II MHC