Diagnosis - Sclerosing adenosis with lobular neoplasia.No invasion in images provided.
Update - Risk with LISN • Meta-analysis 9 studies of 228 patients • 15% ipsilateral, 9% contralateral carcinoma • Ipsilateral 3x more likely than contralateral • A “model of premalignancy for ALH intermediate between a local precursor and a generalised risk for both breasts” • Page DL. Lancet. 2003;361:125-9
Is there a sub-group of pre-invasive LCIS? LCIS with Microinvasion • 6 LCIS with microinvasion described • Nemoto T et al. J Surg Oncol 1998; 67; 41-46
Diagnosis - Fibrocystic change with papillomas and florid usual epithelial hyperplasia
Diagnosis - Fibrocystic change with atypical lobular hyperplasia and flat high grade DCIS