Prevention of retinal detachment in Stickler syndrome: the Cambridge Prophylactic Cryotherapy protocol (2848). Gregory S Fincham, 1 Laura Pasea, 2 Christopher Carroll, 3 Annie M McNinch, 1,4 Arabella V Poulson, 1 Allan J Richards, 4,5 John D Scott, 1 Martin P Snead. 1,4.
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Prevention of retinal detachment in Stickler syndrome: the Cambridge Prophylactic Cryotherapy protocol (2848)
Gregory S Fincham,1 Laura Pasea,2 Christopher Carroll,3Annie M McNinch,1,4Arabella V Poulson,1 Allan J Richards,4,5 John D Scott,1 Martin P Snead.1,4
1Vitreoretinal Service, Cambridge University NHS Foundation Trust, Addenbrooke’s Hospital, 2Centre for Applied Medical Statistics, University of Cambridge, 3School of Health and Related Research, University of Sheffield, 4Department of Pathology, University of Cambridge, United Kingdom, 5Regional Molecular Genetics Laboratory, Cambridge University NHS Foundation Trust, Addenbrooke’s Hospital.
28 year old male
1 vitreous phenotype
Oral giant retinal tear and detachment
and hearing loss
Prophylactic cryotherapy to the ora serrata, where giant retinal breaks are predicted to occur, would reduce the rate of RD in type 1 Stickler syndrome.
Figure 11. Kaplan-Meier plot of unmatched unilateral control versus prophylaxis group
Figure 7. Prevalence of retinal detachment in control versus prophylaxis groups
Figure 9. Kaplan-Meier plot of unmatched bilateral control versus prophylaxis group
In the largest global cohort of type 1 Stickler syndrome patients published to date, all analyses indicate that the Cambridge Prophylactic Cryotherapy protocol is safe and markedly reduces the rate of retinal detachment.
Figure 10. Kaplan-Meier plot of matched bilateral control versus prophylaxis group
Figure 8. Hazard ratios: effect without prophylaxis and 95% confidence intervals (*sex-adjusted)
Figure 12. Kaplan-Meier plot of matched unilateral control versus prophylaxis group