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Biomarkers of AD Progression & Treatment Response: A Study Using Blood Aβ Data from Nilvadipine Trials

This proposed R01 submission focuses on analyzing blood Aβ data from Nilvadipine trials to study AD progression and treatment response. The study aims to examine Aβ, tau, p-tau, miRNA, and phospholipids as biomarkers, and investigate APOE-genotype modification on treatment response. Correlation with imaging and other markers will also be explored.

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Biomarkers of AD Progression & Treatment Response: A Study Using Blood Aβ Data from Nilvadipine Trials

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  1. Proposed R01 submission to the National Institutes of Health

  2. Preliminary Data Blood Aβ data fromNilvadipine ph I/II (Aβ40 increased in AD) Aβ40 reduced with treatment (E3>E4) (SM reduced, ceramide increased in AD) SM increased with treatment Ongoing (progression data) miRNA in longitudinal trials lipidomicin longitudinal trials

  3. Specific Aims Aim 1:To examine blood/CSF Aβ and tau/p-tau in repsonse to treatment in the phase III nilvadipine trial in AD. Aim 2: To examine miRNA and phospholipids as biomarkers of AD progression in the phase III nilvadipine trial of AD. Aim 3: To determine if apolipoprotein (APOE)-genotype dependent modification of treatment response to nilvadipine is detectable by in this biomarker panel. Aim 4: ? Correlation of biomarker response with other markers ie imaging etc.

  4. Specific Aims Aim 1: To correlate Aβ and tau levels in cerebrospinal fluid (CSF) and/or blood with therapeutic response in the phase I/IIanilvadipine trial of AD. Aim 2: To use miRNA in cerebrospinal fluid (CSF) and/or blood for detecting therapeutic response in phase I/IIanilvadipine trial of AD Aim 3: To use phospholipids in cerebrospinal fluid (CSF) and/or blood for detecting therapeutic response in phase I/IIanilvadipine trial of AD.

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