Complement and Mediators of Inflammation. Lecture C4-06M Thursday, November 7, 2002 S TEPHEN R. J ENNINGS , P H .D. Redness. Heat. Pain. Swelling. Overview Of Inflammation. Classic Signs: Swelling, Redness, Heat, Pain, Altered Function. The Complement (C’) System.
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Thursday, November 7, 2002
STEPHEN R. JENNINGS, PH.D.
Overview Of Inflammation
Classic Signs: Swelling, Redness, Heat, Pain, Altered Function
The Complement system consists of a complex series of fifteen proteins, many of which are proteineases.
It is a primitive form of defense against infection, being conserved throughout evolution.
It performs three vital functions:
Is one of the first systems activated in the response to infection.
The Complement system can be considered as a cascade of interacting proteins, acting in a defined manner, resulting in the initiation of important innate biological effects.
C1qrs binds Fc region of IgG
Attack Complex (MAC)
Increased vascular permeability Histamine, bradykinin, C3a, C5a, PGE2,
prostacyclins, Hageman factor.
Vasoconstriction Thromboxane A2, leukotrienes C and D, C5a,
LTB4, formyl peptides
Smooth muscle contraction C3a, C5a, histamine, LTB4,
leukotrienes C and D, thromboxane A2, bradykinin
Increased endothelial cell stickiness IL-1, TNF-a, endotoxin, LTB4
Pyrogens (Fever induction) IL-1, TNF-a, PGE2
Metabolites of Membrane Phospholipids