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The Endocrine System. http://www.brightstorm.com/science/biology/the-human-body/endocrine-system/. Introduction. The endocrine system is the second part of the message-relaying system of the human body It is a system of glands that release chemical messengers into the bloodstream
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The Endocrine System http://www.brightstorm.com/science/biology/the-human-body/endocrine-system/
Introduction • The endocrine system is the second part of the message-relaying system of the human body • It is a system of glands that release chemical messengers into the bloodstream • These messengers are called hormones • These messengers act much more slowly that the neurotransmitters of the nervous system • They must travel through the blood stream to where they are needed – They do, however travel throughout the body
Glands of the Endocrine System • Hypothalamus • A part of the brain that secretes hormones • Tell the pituitary gland to either secrete or stop secreting • This provides a link between the nervous and endocrine system • Also produces hormones that regulate other body processes • These hormones travel to the pituitary for storage until they are needed
Hormones of the Hypothalamus • Antidiuretic Hormone • Stimulates the kidneys to conserve water by producing more concentrated urine • Oxytocin • Stimulates the contractions of childbirth, among other functions
Pituitary Gland (Master Gland) • Pea-sized gland attached to the hypothalamus • Posterior lobe stores hormones from the hypothalamus • Front lobe secretes pituitary hormones • Most of these control other glands
Other Endocrine Glands • Thyroid Gland – in the neck • Hormones increase the rate of metabolism in cells throughout the body • Control how quickly cells use energy and make proteins • Parathyroid gland – located behind the thyroid • Helps keep the level of calcium in the blood within a narrow range • Stimulates bone cells to dissolve calcium in bone matrix and release it into the blood
Other Endocrine Glands • Pineal Gland – located at the base of the brain • Secretes the hormone melatonin which controls sleep-wake cycles and several other processes • Pancreas – located near the stomach • Produces insulin and glucagon • They work together to control blood sugar levels • Insulin causes excess blood glucose to be taken up the by liver and store it as glycogen • Glucagon stimulates the liver to break down glycogen into glucose and release it back into the blood stream • Also secretes digestive enzymes into the digestive tract
Other Endocrine Glands • Adrenal Glands – located above the kidneys • Outer portion secretes cortisol which helps the body deal with stress along with aldosterone which helps regulate mineral balance in the body • Inner portion secretes the fight-or-flight hormones • Adrenalin – increases the among of oxygen and glucose going to the muscles • http://www.abpischools.org.uk/page/modules/hormones/horm8.cfm?coSiteNavigation_allTopic=1
Other Endocrine Glands • Gonads – secrete sex hormones • Testes secrete testosterone • Ovaries secrete estrogen • These two hormones are responsible for the changes of puberty and the control of the production of gametes by the gonads
How do hormones work? • They affect only certain cells called target cells • These target cells have specific receptors on their surface that create a matching combination with its hormone • When the hormone binds to the receptor it causes a change within in the cell • What happens depends upon if the hormone is a steroid or non-steroid • http://www.wisc-online.com/objects/ViewObject.aspx?ID=AP13704 • http://www.youtube.com/watch?v=HrMi4GikWwQ&feature=related
Steroid Hormones • Made of lipids like phospholipids and cholesterol • They are fat soluble so they can diffuse through the plasma membrane of target cells and bind with the receptors in the cytoplasm
Non-Steroid Hormones • Made of amino acids • They are not fat soluble so they can’t diffuse across the plasma membrane • When they bind the trigger enzymes within the cell membrane the active other molecules
Hormone Regulation • Typically Controlled by feedback mechanisms • This is a loop in which a product (hormone) feeds back to control its own production • Most involve negative feedback loops • Keeps the concentration within a very narrow range
Negative Feedback http://www.youtube.com/watch?v=CLv3SkF_Eag
Endocrine System Disorders • Hypersecretion • Too much • Usually caused by a tumor • Too much growth hormone leads to gigantism • Hyposecretion • Too little • Type I diabetes
Hormone Resistance • Normal amounts of hormone but target cells do not respond to the hormones • Type II diabetes • Cells don’t take up glucose • Need to follow a specific diet along with medication • Insulin doesn’t work