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Feedback Control for the Pro grammable Cell Culture Chip “ ProCell ”. Felician Ștefan Blaga Supervisor : Paul Pop (DTU Informatics) Co-supervisors: Wajid Minhass (DTU Informatics) and Martin Dufva (DTU Nanotech ). Outline. Early design phases Design decisions and uncertainties

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feedback control for the pro grammable cell culture chip procell

Feedback Control for the Programmable Cell Culture Chip “ProCell”

FelicianȘtefanBlaga

Supervisor: Paul Pop (DTU Informatics)

Co-supervisors: WajidMinhass (DTU Informatics) and Martin Dufva (DTU Nanotech)

outline
Outline
  • Early design phases
    • Design decisions and uncertainties
  • Modeling uncertainties
    • Worst-case execution time
    • Functionality requirements
  • Problem formulation: mapping optimization
    • Motivational examples
  • Multi-objective optimization strategy
    • Robustness vs. flexibility
    • Genetic Algorithm approach
    • Experimental results
  • Conclusions and message
motivation for biochips
Motivation for Biochips

Automation

Automation

Automation

Integration

Integration

Integration

Miniaturization

Miniaturization

Miniaturization

Test tubes

Robotics

Microfluidics

two types of microfluidic biochips
Continuous-flow biochips: Permanently-etched microchannels, micropumps and microvalves, electrokinetics, etc.

Digital microfluidic biochips: Manipulation of liquids as discrete droplets

Two types of microfluidic biochips

Multiplexing

Mixing: Static, Diffusion Limited

Biosensors:

Optical: SPR, Fluorescence etc.

Electrochemical: Amperometric, Potentiometric etc.

application area cell culturing
Application area: cell culturing
  • TODO Some text about cell culturing
procell setup
ProCellsetup
  • Requirements:
    • 1
    • 2
  • Components
    • 1
    • 2
procell control diagram
ProCell control diagram

PC

Microscope

Procell Prototype

Motors controlling the pumps

Signal adaptor

LabJack

Explanations, color change…

Explanations

Explanations

procell prototype
ProCell prototype

The biochip is fabricated using micro-milling prototyping

zeiss microscope
Zeiss Microscope
  • Something about the microscope and the AxioVision Software
  • Something about fluorescence
control box
Control box
  • Something about the control box, and difficulties in putting everything together (you had to order the box, etc.)
  • What you will cover next:
    • LabJack
    • Signal adapter board
labjack
LabJack
  • What is a LabJack? (copy paste from the thesis)
  • How is it controlled?
signal adapter board
Signal adapter board
  • Some explanations about the motors
    • Use sub-bullets if needed
  • Something about the board and why you needed the counter

Step motor FaulhaberAM1524

Ripple counter

three types of control
Three types of control
  • Direct control
    • Short text about it—take it from the thesis and be succinct
  • Scenario-based control
    • Short text about it
  • Feedback control
    • Short text about it
scenario based control
Scenario-based control
  • Focus on VBA
    • Tell us what is on the left
    • Tell us what you did with VBA
feedback control
Feedback control

Main part

Scripts control

LabJack control

Excel interface

R

P

M

-

  • Explain the feedback control
  • Tell us about VBA
  • Maybe we need two slides?

Ref

evaluation direct control
Evaluation: direct control
  • What do we see in the picture
  • How is the control achieved
evaluation scenario based control
Evaluation: scenario-based control
  • What do we see in the picture
  • How is the control achieved
evaluation feedback control
Evaluation: feedback control
  • No Feedback
    • What do we see in the picture
    • How is the control done
  • With feedback
    • What do we see in the picture
    • How is the control done
  • What is the conclusion
evaluation feedback control1
Evaluation: feedback control
  • Remind what is fluorescence
  • What do we see in the picture
  • How was the control done
  • Conclusion: why is it good
conclusions
Conclusions
  • ProCell setup: cell culturing biochip, microscope, proposed control box
  • Several control approaches, using VBA and the control box
    • Direct control
    • Scenario-based control
    • Feedback control
    • The control solution has been systematically evaluated and tested
  • The solution is successfully used in the field
    • DTU Nanotech
    • Danish Cancer Society
    • University of Oslo
    • Bioneer
  • The work done in the thesis has been partly reported in two scientific papers