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Pharmacology. Neonatal Pediatric. Bronchodilators. Beta II agonists ( sympathomimetics ) Albuterol and Lev- albuterol Bronchodilates Mild anti-inflammatory Improves mucocilliary clearance Racemic Epinephrine Upper airway swelling Croup Post extubation. Bronchodilators.

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pharmacology

Pharmacology

Neonatal Pediatric

bronchodilators
Bronchodilators
  • Beta II agonists (sympathomimetics)
    • Albuterol and Lev-albuterol
      • Bronchodilates
      • Mild anti-inflammatory
      • Improves mucocilliary clearance
    • Racemic Epinephrine
      • Upper airway swelling
        • Croup
        • Post extubation
bronchodilators1
Bronchodilators
  • Anticholinergic (parasympatholytic)
    • Ipratropium bromide (Atrovent)
      • May react to this drug if they are allergic to peanuts
anti inflammatory
Anti-inflammatory
  • Inhaled steroids
    • Pulmacort for SVN
    • Many others for MDI and DPI
  • Mast Cell stabilizers
    • CromolynSodium(Intal)
    • Nedocromyl Sodium (Tilade)
anti inflammatory1
Anti-inflammatory
  • Prednisone, oral
  • Solumederon, IV
  • Decadron, IV
mucolytics
Mucolytics
  • Mucomyst (Acetylcystiene)
    • Breaks up mucus
    • Very irritating
  • Pulmozyme
    • Breaks down white blood cells
    • Need infected sputum with WBCs to be effective
anti infectives
Anti infectives
  • Tobramycin (Tobi)
    • Antibiotic
    • Infected sputum
  • Pentamidine
    • PCP
  • Ribaviron
    • RSV
methylxanthines
Methylxanthines
  • Theophyline
    • Mild bronchodilator
    • Increases drive to breath
    • Used on children in place of steroids
  • Caffiene
    • Used to treat apnea in newborns
slide9
MISC
  • Leukotrienes
  • Antihistimines
    • Both work to stop the inflammatory reaction at different points in the process, as do steroids also
  • Magnesium Sulfate
    • Promotes bronchodilation in children