VIROLOGY. Allgemeine Virologie I. Introduction in Virology. History January 1796 vaccination against smallpox virus. Virus. Definition of virus Basic properties of viruses Morphology – Structures of virues Replication Classification. Bacteriophage. Basic Virology.
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Introduction in Virology
January 1796 vaccination against smallpox virus
Effect of viral replication CPE – Pathogenesis
European governments have officially encouraged or compelled the practise; and smallpox has ceased to be the almost universal scourge it was before Jenner's discovery.
Modern History Sourcebook
Some are asymptomatic!
“A PIECE OFBAD NEWSWRAPPED UP IN A PROTEIN”
1. smallest infectious agents
2. one kind of nucleic acid (RNA or DNA)
3. intracellular parasites
4. assembly of the individual components
5. not usually respond to antibiotics
Virion: the complete fully assembled virus, serves to transfer the viral nucleic acid
Range: from 20nm to 300nm in diameter
Shapes: spheres, rods, bullets, bricks, tadpoles
A complete infectious particle of virus
( 65 ×95nm )
( 40nm )
( 100nm )
Shapes of Viruses :Rod-shaped
Shapes of Viruses :Brick-shaped
Shapes of Viruses:Bullet-shaped
Shapes of Viruses :Filament
Function: It provide the information of reproduction, heredity and mutation.
 Viral protein
 Viral nucleic acid
 Viral lipid
 Viral glycoprotein
1.The structural proteins of viruses:
(1) Capsid protein
(2) Basic core protein
These proteins are necessary to package the nucleic acid within the capsid !
The non-structural proteins are other proteins such as enzymes that are needed for the production of viral components but are not part of the virion.
1. Protect the nucleic acid
2. Take part in infection
Six different classes can be distinguished, based on mechanisms of transcription.
1. +-dsDNA 2.+ssDNA
3. +- dsRNA 4.+ssRNA
5.–ssRNA 6.Retroviruses +ssRNA
mediate the attachment of the virus to specific receptors on the host cell surface