Module 4: Process Analytical Technology. Module 4 Purpose and Objectives. Module Purpose: Examine PAT in the context of lyophilization Module Objectives: After this module, you will Have been introduced to the instrumentation used in lyophilization Argue for or against PAT proposals.
Do something with the measurements to cause a change during the cycle.
measurement is a chamber average.
Water vapor penetrates the gold layer and into the Aluminum Oxide Dielectric. Capacitance is proportional to the water absorbed.
Functions by measuring the temperature on either side of a heater that is in a laminar flow. The gas stream is a side stream on the flow and the output is proportional to the mass within the sample at all times.
Research Method – Not yet in prime time.
Research Method – Not Yet in Prime Time
Proposed in the literature – not in practice
Robotic balance that periodically picks up the vial and determines its weight.
Currently used only for development.
*Most dew point measurements are notoriously inaccurate