microRNAs : genome regulators. Aizhan Bizhanova. Overview. miRNA What are miRNAs ? Function and role C.elegans Role of miRNAs in developmental genetics of C.elegans lin-4 miRNA , “precocious” and “retarded” phenotypes Drosophila let-7 miRNA affects neuronal cell differentiation?.
1.Transcribing the primary miRNA (pri-miRNA)
2. Nuclear processing of pri-miRNA
3. Export of pre-miRNA from the nucleus to the cytoplasm by Exportin5
4. Cytoplasmic processing of pre-miRNA
5.Loading of miRNA duplex into RISC
Vella and Slack, 2005
Taken from Sokol, presentation