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Alzheimer’s

Alzheimer’s. Causes and Effects of the Common Brain Disorder. Type of Inheritance. Polygenic Autosomal Dominance Disorder. One Gene has to be dominant Every race can be affected. Genotype. An Affected Dominant male, and a Heterozygous carrying female.

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Alzheimer’s

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  1. Alzheimer’s Causes and Effects of the Common Brain Disorder

  2. Type of Inheritance • Polygenic Autosomal Dominance Disorder. • One Gene has to be dominant • Every race can be affected

  3. Genotype An Affected Dominant male, and a Heterozygous carrying female A= Alzheimer's. Both have to be Dominant Affected XA XA XAXa XAXa Xa Affected Affected XAY XAY Y

  4. Pedigree Blue is affected

  5. Population Statistics • 1:10 over 65 • There are about 4 million people with Alzheimer's and other related diseases • Data shows that by the year 2050, the population could increase to at least 11.5 million!

  6. Diagnosed • Process of elimination • Family history • Symptoms • All diagnostics are only seen with elderly people. • It is not probable to see symptoms in children

  7. Proteins Affected • APP, PSEN1, PSEN2- Type A1,3,4 • Produce large amounts of toxic proteins • APOE- type 2 • Same disorder

  8. Treatment • Drugs • Specialized hospitals • Non-pharmaceutical therapy

  9. Physical Symptoms • Forget names • Forget certain words • Forget location of everyday objects • Denial • Blames others for mishaps • Rage

  10. Life of individual • Wake up delusional • Forget where they are • Don’t know where the kitchen is, let alone where the objects are • Visits from “friends” when they are actually family • Bed • Isn’t their life fun?!

  11. Family Help • Since the affected person doesn’t realize that they have Alzheimer's, it is up to the family to take care of them • Live with the person, or send them to a hospital

  12. Is it Curable? • At this day and time, no. • It is only treatable. • But with the advancements in medical technology, scientists and genetic engineers believe that the cure will be 50% complete, within 50 years

  13. Nutshell • Polygenic Autosomal Dominant • 1:10 • One gene has to be dominant • Memory loss • No Cure

  14. References • Medline • Mayo clinic of Alzheimer’s Disease and other Disorders • www.alzheimers.org/

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