Abstract N0. 1063
Download
1 / 1

Summary: - PowerPoint PPT Presentation


  • 86 Views
  • Uploaded on

Abstract N0. 1063. 188. 171. 158. 132. 68. 18. 265. 231. 207. 175. 98. 25. 200. 171. 151. 128. 80. 25. 31. 28. 27. 24. 14. 5. 92. 83. 75. 61. 36. 13.

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'Summary:' - vida


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
Summary

Abstract N0. 1063

188

171

158

132

68

18

265

231

207

175

98

25

200

171

151

128

80

25

31

28

27

24

14

5

92

83

75

61

36

13

Effect of Hysterectomy and Lymph Node Dissection Plus Radiation on Survival in Patients with Stage I Grade 3 Endometrial Adenocarcinoma

Johnny Yap, Paul Chuba, Merlin Hemre

Shashikant Lele, Wainwright Jaggernauth, Amr Aref

Roswell Park Cancer Institute, Buffalo, New York

Conclusions and Discussion:

SEER data suggest that more extensive surgery including LND together with radiation treatment may result in greater overall survival in localized FIGO stage I, node-negative, but high grade endometrial AdenoCa

This result is subjected to selection-bias due to the nature of the data. Quality of data is presumably accurate, but reasons for a particular patient to undergo LND is not known The patients who were surgically stage I may have an inherently improved outcome as compared to clinically stage I diesease.

Interestingly, the type of RT did not impact on overall survival. All patients received some form of RT in this series. Could brachytherapy alone be sufficient while omitting XRT? This

series cannot answer that due to the small sample size.

Summary:

Selective lymphadenectomy is commonly employed for management of early stage endometrial cancer. We have used SEER data to evaluate the impact of lymph node dissection, LND, (pelvic and para-aortic areas) on survival (OS).

SEER database (1988 to 1997) was used for this analysis. A total of 425 patients were identified, and 205 patients had LND while 220 patients had no LND. All patients had some form of adjuvant radiation treatment.

On multivariate analysis, the use of LND remained a significant prognosticator. On univariate analysis, RT types (XRT vs. brachytherapy alone vs. combined) and race did not impact OS. The use of LND resulted in improved 10-year OS at 67.5% vs. 53% (p=0.01)

Patient Characteristics:

Surgery N RT Race Age

type type

_____________________________________________________

No LND 220 XRT 165 C 208 35 to90

Brachy 11 AA 12 median

Both 44 68

Yes LND 205 XRT 128 C 195 37 to 87

Brachy 23 AA10 median

Both 54 66