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Effects of HGF Treatment on Phospho-ERK1/2 and MEK1/2 Activation in Huh7 Cells

This study investigates the impact of Hepatocyte Growth Factor (HGF) on the activation of ERK1/2 and MEK1/2 pathways in Huh7 cells. Using phospho-specific assays, we measured the percentage of control for Phospho-ERK1/2 and Phospho-MEK1/2 at various time points (0.15, 30, 60, 120 minutes) following HGF treatment. Additionally, Ras-GTP activation was also assessed under the same conditions. Results demonstrate a significant temporal response of these signaling pathways to HGF stimulation, highlighting their role in cellular signaling.

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Effects of HGF Treatment on Phospho-ERK1/2 and MEK1/2 Activation in Huh7 Cells

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  1. PLC/PRF/5 A Phospho-ERK1/2 (% of control) HGF(min) B C Phospho-MEK1/2 (% of control) 0 15 30 60 120 0 15 30 60 120 Ras-GTP (% of control) HGF(min) HGF(min) 0 15 30 60 120 Huh7 D E Phospho-ERK1/2 (% of control) Phospho-MEK1/2 (% of control) F HGF(min) 0 15 30 60 120 HGF(min) 0 15 30 60 120 Ras-GTP (% of control) HGF(min) 0 15 30 60 120 Supplementary Fig. 2

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