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Analysis of Rat Place Cells in Enlarged CA1 Region

This study explores rat place cells in an enlarged CA1 region using a diagram to show neuronal recordings during different environments and tasks, such as running in a triangular path. The reliability of the obtained data is assessed, discussing the methodology used and the implications for understanding neural activity in the brain.

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Analysis of Rat Place Cells in Enlarged CA1 Region

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  1. HC Place cells taxi drivers enlarged CA1 region Rat place cells How was this diagram obtained? How reliable is it? rat running in triangular path McNaughton et al (1996) J Exp Biol 199, 173–185

  2. Colours represent different neurons

  3. recordings separated by 1 hr in home cage recordings separated by 6 hours of novel environments

  4. The recording environment consisted of a moderately illuminated room, with a raised triangular track located in the middle. The rat’s task was to move continuously in one direction around the track to receive food reinforcement at the mid-point of each side

  5. Note this is actually a restrained rat, being gently moved around It all began… 400 ms O'Keefe J, Dostrovsky J. Brain Res. 1971 Nov;34(1):171-5. [on VLE]

  6. Multiple electrodes Use a computer to do spike recognition O'Keefe &. Recce (1993) Hippocampus 3, 317–330

  7. LEDs to track head position and direction Inbuilt FET amplifier, 14 x 4 Gothard et al (1996) J Neurosci: 16:823-835

  8. Freely moving rat O’Keefe (1976) Experimental neurol 51, 78-109 (1976)

  9. Place unit 202-2. There is a smaller high-frequency displace unit in the background O’Keefe (1976) Experimental neurol 51, 78-109 (1976)

  10. trained to forage in T-maze light, buzzer, fan, white card, O'Keefe Conway (1978) Exp. Brain Res. 31,573-590

  11. place cells [2 and 3] firing as rat ran along runway theta rhythm of EEG speed of rat O'Keefe &. Recce (1993) Hippocampus 3, 317–330

  12. Precession at end of rhythm at start of rhythm

  13. rats foraging over platform record CA1 pyramidal cells in theta θ rhythm Skaggs et al (1996) Hippocampus 6:149-172

  14. Place cells fire out of θphase where was the max firing of this pyramidal cell? where was rat when θ was max? Skaggs et al (1996) Hippocampus 6:149-172

  15. Review • Are the CA1 cells firing at random? • Are the CA1 neurons firing to • place • some other activity • motivation? http://biolpc22.york.ac.uk/750/mem/place_cells.ppt

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