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HC Place cells. taxi drivers enlarged CA1 region Rat place cells How was this diagram obtained? How reliable is it?. rat running in triangular path. McNaughton et al (1996) J Exp Biol 199 , 173–185. Colours represent different neurons. recordings separated by 1 hr in home cage

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Hc place cells
HC Place cells

taxi drivers enlarged CA1 region

Rat place cells

How was this diagram obtained?

How reliable is it?

rat running in triangular path

McNaughton et al (1996) J Exp Biol 199, 173–185



Hc place cells

recordings separated by 1 hr in home cage

recordings separated by 6 hours of novel environments


Hc place cells

The recording environment consisted of a moderately illuminated room, with a raised triangular track located in the middle. The rat’s task was to move continuously in one direction around the track to receive food reinforcement at the mid-point of each side


It all began

Note this is actually a restrained rat, being gently moved around

It all began…

400 ms

O'Keefe J, Dostrovsky J. Brain Res. 1971 Nov;34(1):171-5. [on VLE]


Multiple electrodes
Multiple electrodes around

Use a computer to do spike recognition

O'Keefe &. Recce (1993) Hippocampus 3, 317–330


Hc place cells

LEDs to track head position and direction around

Inbuilt FET amplifier, 14 x 4

Gothard et al (1996) J Neurosci: 16:823-835


Freely moving rat
Freely moving rat around

O’Keefe (1976) Experimental neurol 51, 78-109 (1976)


Hc place cells

Place unit 202-2. There is a smaller high-frequency displace unit in the background

O’Keefe (1976) Experimental neurol 51, 78-109 (1976)


Hc place cells

trained to forage in T-maze unit in the background

light, buzzer, fan, white card,

O'Keefe Conway (1978) Exp. Brain Res. 31,573-590


Hc place cells

place cells [2 and 3] firing as rat ran along runway unit in the background

theta rhythm of EEG

speed of rat

O'Keefe &. Recce (1993) Hippocampus 3, 317–330


Precession
Precession unit in the background

at end of rhythm

at start of rhythm


Hc place cells

rats foraging over platform unit in the background

record CA1 pyramidal cells in theta θ rhythm

Skaggs et al (1996) Hippocampus 6:149-172


Place cells fire out of phase
Place cells fire out of unit in the backgroundθphase

where was the max firing of this pyramidal cell?

where was rat when θ was max?

Skaggs et al (1996) Hippocampus 6:149-172


Review
Review unit in the background

  • Are the CA1 cells firing at random?

  • Are the CA1 neurons firing to

    • place

    • some other activity

    • motivation?

http://biolpc22.york.ac.uk/750/mem/place_cells.ppt