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Adaptive changes of maternal bone and intestine during lactation

Adaptive changes of maternal bone and intestine during lactation. Asst. Prof. Kannikar Wongdee , Ph.D. Office of Academic Management, Faculty of Allied Health Sciences, Burapha University Center of Calcium and Bone Research (COCAB), Faculty of Science, Mahidol University

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Adaptive changes of maternal bone and intestine during lactation

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  1. Adaptive changes of maternal bone and intestine during lactation Asst. Prof. KannikarWongdee, Ph.D. Office of Academic Management, Faculty of Allied Health Sciences, Burapha University Center of Calcium and Bone Research (COCAB), Faculty of Science, Mahidol University E-mail: kannikar@buu.ac.th OHEC congress at Ambassador City Jomtien, Chonburi September 14, 2012

  2. Bone Hematopoiesis Protect internal organs Dkimages.com, 2008; Anatowiki.com, 2008; Fitsugar.com, 2008; Wikimedia.org, 2008 99% of calcium is stored in bone. Site for muscle attachment Locomotion

  3. Bone mass throughout life Picture: www.health.com; www.5election.com Not only post-menopausal period, pregnancy and lactation also induce massive bone loss. Bowman and Miller, J Musculoskel Neuron Interact, 2001; Charoenphandhu et al. Trends EndocrinolMetab, 2010

  4. Maternal calcium metabolism Charoenphandhu et al., Trends EndocrinolMetab, 2010 Charoenphandhu et al. Trends EndocinolMetab, 2010 • Maternal calcium loss • Fetal transfer during pregnancy (third trimester) • Milk production (requires more calcium) • Calcium supply during lactation • Bone — bone resorption • Diet — intestinal calcium absorption

  5. Adaptive changes of maternal intestine and bone • Technical approach • Histomorphometry: bone histomorphometry, micro-CT • Cell biology and molecular biology techniques: PCR, immunohistochemistry Picture:www.albany.edu; www.boripat.ac.th

  6. Maternal villous hypertrophy during lactation Picture: www.humpath.com Wongdee et al., J MolHistol, 2012 Wongdee K, Teerapornpuntakit J, Siangpro C, Chaipai S, Charoenphandhu N. Duodenal villous hypertrophy and upregulation of claudin-15 protein expression in lactating rats. Journal of Molecular Histology 2012 (in press).

  7. Maternal bone loss during lactation Osteoclast surface Eroded surface Picture: www.health.com P = pregnancy; L = lactation; PW = postweaning Suntornsaratoon et al., Am J PhysiolEndocrinolMetab, 2010 • Human — up to 10% of skeletal mass • Lactation-induced osteoporosis (Ofluoglu and Ofluoglu, 2008) • Rodent (6–8 pups) — up to 30% of skeletal mass • Partly under the regulation of PRL

  8. Roles of PRL on maternal calcium metabolism Charoenphandhu N, Wongdee K, Krishnamra N. Is prolactin the cardinal calciotropic maternal hormone? Trends in Endocrinology & Metabolism 2010;21(7):395‒401.

  9. Endochondral bone changes during lactation Growth plate height Bone length Suntornsaratoon et al. Histochem Cell Biol, 2010 Wongdee et al. J PhysiolSci, 2012 • Lactation-induced elongation of the long bone. • PRL-induced decreases in total growth plate height.

  10. Perspective plan • Fibroblast growth factor 23 (FGF23), bone-derived phosphate-regulating hormone • Existence of FGF receptors in the intestinal villi. • FGF23 compromised the 1,25(OH)2D3-induced intestinal calcium absorption. Khuituan et al. Am J PhysiolEndocrinolMetab, 2012 Role of FGF23 in bone and intestine during pregnancy and lactation

  11. Acknowledgements Assoc. Prof. NarattapholCharoenphandhu, M.D., Ph.D. MU Prof. NateetipKrishnamra, Ph.D. MU ChitchamaiSiangpro, B.Sc. BUU SunitraChaipai, B.Sc. BUU PananSuntornsaratoon, M.Sc. MU NatchayapornThonapan, B.Sc MU JarinthornTeerapornpuntakit, M.Sc. MU Research grants Office of the Higher Education Commission Faculty of Allied Health Sciences, Burapha University Thailand Research Fund (TRF) NSTDA

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