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Understanding TNF Signaling Pathway Regulation: Role of Adaptor Proteins and MAPK Cascades

Learn about TNF and TNF-R signaling, the involvement of Adaptor proteins like TRAF2, and the MAPK cascade including MEKK1, ASK1, TAK1, MAPKKK, MAPKK, and multiple MKKs leading to activation of MAPKs such as JNK and p38. The pathway's effects on transcription factors like cJun and ATF2 are also explained.

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Understanding TNF Signaling Pathway Regulation: Role of Adaptor Proteins and MAPK Cascades

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  1. TNFa TNF-R Adaptor proteins TRAF2 MEKK1 ASK1 TAK1 MAPKKK MAPKK MKK7 MKK4 MKK3 MKK6 MAPK JNK p38 Transcription factors cJun ATF2 Figure 2

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