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Kelompok 4:

Kelompok 4:. Gigih Aditiya P G1F009027 Gatot Setyo W G1F009050 Winanto G1F009066 Rani Febriyanti G1F009068 Amalia Ulfa G1F011001 Iin Solihati G1F011013 Alfianita G1F011031 Desy Damayanti G1F011033 Nurlaela Yuni A G1F011047 Ines Nur Hendriyani G1F011051

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Kelompok 4:

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  1. Kelompok 4: • Gigih Aditiya P G1F009027 • Gatot Setyo W G1F009050 • Winanto G1F009066 • Rani Febriyanti G1F009068 • Amalia Ulfa G1F011001 • Iin Solihati G1F011013 • AlfianitaG1F011031 • Desy Damayanti G1F011033 • Nurlaela Yuni A G1F011047 • Ines Nur Hendriyani G1F011051 • Intan Diah P G1F011069 • Fela Anggia SP G1F011071 • Najah G1F011075

  2. Fungsi Kanal Ion Cl- Sub tipekanalCl- CFTR CLC-2

  3. FungsiKanalCl- 1. Regulasi volume dan homeostasis ionik 2. Transport transepithelial 3. Regulasi eksitabilitas elektrik

  4. Kanal CFTR

  5. Cystic Fibrosis Cystic Fibrosis disebabkanadanyamalfungsi darikanalkloridaCl-CFTR. Beberapaobat yang bisamenstimulasipembukaankanal ion Cl-CFTR adalahgenistein,flufenamid,dan tolbutamid. Hal initerjadikarenamenumpuknyacairan mukuspadasaluran (prnafasan,pencernaan,testis,danpankreas).

  6. Voltage Gated Chloride Channels (CLCs)

  7. Lubiprostone Kanal ion padasisiapikal (kanal CLC) bilaberikatandenganagonis (lubiproston) akanmembukasehingga ion kloridaakankeluardariselepitalialmenuju lumen usus.

  8. Lubiprostonmengaktivasikanal CLC-2 intestinal

  9. TERIMAKASIH….

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