SUPRARENAL GLANDS DISEASES. L ecturer : Sakharova I.Ye. M.D. A Close Look at the Adrenal Glands. Adrenal glands hyperfunction:. Adrenal glands hypofunction:.
Lecturer: Sakharova I.Ye. M.D.
Endogenous(ACTH dependent 85%)
ACTH independent 15%
In children the dominant clinical features are cessation of linear growth and weight gain; the clinical course is more aggressive than in adults.
Screening tests (outpatient)
In normal subjects, administration of a supraphysiological dose of glucocorticoid results in suppression of ACTH and hence of cortisol secretion (cortisol <50 nmol/l). This is the basis of dexamethasone suppression tests, of which there are several types.
Another name for the condition is primary hyperaldosteronism.
3. Adrenal Carcinoma (rare)
4. Unilateral Adrenal Hyperplasia (very rare)
B. Increased serum level of aldosterone
C. Greatly decreased serum level of renin
Blood may also be taken directly from the adrenal veins (via a catheter passed through a vein in the inguinal region) to determine whether both adrenals are over-secreting aldosterone.
B. Adrenal Hyperplasia