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Fig. 13-1, Page 307 PowerPoint Presentation
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Fig. 13-1, Page 307

Fig. 13-1, Page 307

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Fig. 13-1, Page 307

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  1. C N Gene Expression Fig. 13-1, Page 307

  2. Deoxyribonucleotide Pg. 242

  3. DNA Bases Pg. 242

  4. Deoxyribonucleotide A Pg. 242

  5. DNA Strand Pg. 244

  6. 5’ 3’ 3’ 5’ DNA Structure Fig. 1-8,Page 5

  7. Base Pair Structures Pg. 368

  8. Ribonucleotide OH Pg. 242

  9. RNA Bases Pg. 242

  10. Fig. 13-7,Page 314

  11. Possible Reading Frames for RNA

  12. Fig. 13-7,Page 314

  13. Mutation (Chapt. 15) Classification of mutations Mechanisms of mutagenesis DNA repair pathways

  14. Old Old DNA Replication Template-dependent Semi-conservative Old New Old New Pg. 264

  15. Thymine Base Pairing Standard AT Base pair Tautomeric Shift Base pair Pg. 368

  16. A A C T C A G T G C G T Tautomeric Shift Base Pairs Standard Base Pairs Rare tautomers are shown in Red

  17. DNA molecule with TA CG transition mutation Affected base pair Tautomeric Shift of “A” Pg. 369

  18. “Spontaneous” Insertion/Deletion Mutations

  19. Pg. 371

  20. Ethylmethane Sulfonate Mutagenesis Pg. 370

  21. Intercalating Agents Ethidium Bromide

  22. Intercalation

  23. Electromagnetic Spectrum (XP Photosensitivity: 280 to 310 nm) Pg. 371

  24. DNA damage induced by UV light Fig. 15-9 Pg. 372

  25. Nucleotide Excision Repair (NER) Pathway

  26. Normal Sickle Cell Anemia Sickle Cell Trait

  27. Hemoglobin ß-globin (146 amino acids) ß-globin (146 amino acids)

  28. Molecular Genetics of Sickle-Cell Anemia HbA Allele Codon #6 Hb-A HbS Allele Hb-S

  29. Hb-A Hb-S Pg. 350

  30. HbAHbA HbSHbS HbAHbS

  31. Mutant ß-globin Proteins Hb-A

  32. Missense mutation Nonsense mutation Frame-shift mutation Deletion, in-frame Chloride Ion Channel Gene and Protein Involved in Cystic Fibrosis CFTR Gene Mutations

  33. Lung epithelial cells Lung epithelial cells Healthy Lung AA or Aa

  34. Lung epithelial cells Lung epithelial cells Cystic Fibrosis Lung aa

  35. Huntington’s Disease

  36. Huntingtin protein aggregates Cell from “Hh” individual

  37. Huntington’s Disease

  38. Trinucleotide Repeat Diseases

  39. Genetic Technologies Genetic Testing Gene Therapy Genomics

  40. Genetic Testing “Carrier” Testing Presymptomatic Testing Pre-implantation Embryos (PGD) Prenatal (amniocentesis, CVS) Newborns Adults

  41. Molecular Genetics of Sickle-Cell Anemia HbA Allele Codon #6 Hb-A HbS Allele Hb-S

  42. Genetic Testing for Sickle Cell Anemia HbS HbA Fig. 22-9 Pg. 556 MstII cut sites

  43. Pre-implantation Genetic Diagnosis (PGD) Remove one cell for genetic testing 8 cell Embryo from IVF

  44. Genetic Technologies Genetic Testing Gene Therapy Genomics

  45. Viral Vectors for Gene Therapy Removal viral genes Splice in therapeutic gene

  46. Gene Therapy for Severe Combined Immunodeficiency Cloned “A” allele “aa” individual Virus with “A” allele “aa” cells “Aaa” cells Fig. 22-10 Pg. 561

  47. CF Gene Therapy Adenovirus with Wild Type CFTR Allele