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Blood gas transport. Lectures on respiratory physiology. CONCENTRATION AND PARTIAL PRESSURE. O 2 MOLECULES IN AIR. DRY AIR: 21% IS OXYGEN. [O 2 ] = 21 ml/dl FO 2 = 0.21. As P B = 760 mm Hg. PO 2 = 0.21 x 760 mm Hg. = 160 mm Hg. EFFECT OF WATER VAPOR.
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Blood gas transport Lectures on respiratory physiology
CONCENTRATION AND PARTIAL PRESSURE O2 MOLECULES IN AIR DRY AIR: 21% IS OXYGEN [O2] = 21 ml/dl FO2 = 0.21 AsPB = 760 mm Hg PO2 = 0.21 x 760 mm Hg = 160 mm Hg
EFFECT OF WATER VAPOR 37oC PB = 760 mm Hg PH2O = 47 mm Hg PDRY = 713 mm Hg PO2 = 0.21 x 713 mm Hg = 150 mm Hg
O2 IN PHYSICAL SOLUTION 37oC WATER AFTER EQUILIBRATION, AIR: PO2 = 150 mm Hg AIR WATER: PO2 = 150 mm Hg AIR: [O2] = 21 ml/dl WATER: [O2] = 0.45 ml/dl 37oC SOLUBILITY = 0.45 / 150 = 0.003 ml/(dl.mmHg)
TRANSPORT OF O2 IN SOLUTION DURING EXERCISE Solubility = 0.003 ml/(dl.mmHg) PO2 in arterial blood = 100 mm Hg [O2] = 0.3 ml/dl = 3 ml/liter Cardiac output = 30 liters/min Maximum O2 available = 90 ml/min But O2 requirement is 3000 ml/min
Normal cells Sickle cells
ARTERIAL BLOOD VENOUS BLOOD P50 27
TOTAL O2 IN BLOOD IS THE SUM OF Hb-BOUND AND DISSOLVED O2 TOTAL [O2] = 1.39 x [Hb] x % SATURATION/100 + 0.003 x PO2
TOTAL O2 IN ARTERIAL BLOOD (1.39 x 15 x 0.97) + (0.003 x 100) = 20.5 ml/dl
CO-Hb DISSOCIATION CURVE CO SATURATION, % O2 PARTIAL PRESSURE, mm Hg
Carbon dioxide is carried in the • blood in three forms • Dissolved • As bicarbonate • 3. As carbamino compounds
Solubility of Oxygen 0.003 ml/(dl.mmHg) Solubility of Carbon Dioxide 0.067 ml/(dl.mmHg)
Formation of bicarbonate C.A. CO2 + H2O H2CO3 H2CO3 H+ + HCO3-
Formation of carbamino compounds Hb.NH2 + CO2 Hb.NH.COOH