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Explore the intricacies of the respiratory system, from the lungs to gas exchange in the alveoli. Learn about the conducting and respiratory portions, defense mechanisms, and the vital role of each component in breathing.
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RESPIRATORY SYSTEM dr. SOENANTO ROEWIJOKO, MS, SpA
THE RESPIRATORY SYSTEM LUNGS SYSTEM OF TUBE • VENTILATION MECHANISM • Thoracic cage • Intercostal muscle • Diaphragm • Elastic & collagen (of the lungs)
Tonsil NASOFARING PLICA VOCALIS CONUS ELASTICUS
2 PRINCIPLES REGION A CONDUCTING PORTION A RESPIRATORY PORTION
Nasal cavity Nasopharynx Larynx Trachea Bronchi Bronchioles Terminal bronchioles Gas exchange: - Resp. bronchioles - Alveoli ducts - Alveoli
2 MAIN FUNCTIONS OF THE CONDUCTING PORTION • To provide a conduit through which air can travel to and from lungs • To condition the inspired air • Cleansed • Moistened and warmed by: • Respiratory ephitelium • Mucous and serous glands • A rich vascular network
RESPIRATORY EPHITELIUMCiliated pseudostratified Columnar ephiteliumwithGoblet cells 5 Cells (with EM): • Ciliated columnar cells • Mucous goblet cells • Columnar brush cells • Basal cells • Small granule cells
NASAL CAVITY VESTIBULE NASAL FOSSAE • Nares (nostril) • Vibrissae • Sebaceous & sweat glands • Nasal septum • Conchae: • - sup, mid, inf. • Venous plexuses • (of Kiesselbach)
OLFACTORY EPHITELIUM ORGANIZATION Modified pseudostratified columnar epith. • Bipolar neurons cells • Sustentacular cells • Basal cells
MUCOUS SECRETION
OLFACTORY EPHITELIUM ORGANIZATION Mechanism of smell Odor molecules stimulate receptors Transduction process Toward the central nervous system
Acute Chronic PARANASAL SINUSES • Frontal • Maxillary • Ethmoid • Sphenoid • Thinner resp. epithelium • Few goblet cells • Few small glands • Thinner lamina propia periost • Sinusitis : Inflammatory process of the sinus
PHARYNX • Nasopharynx • Respiratory type epithelium • Oropharynx • Squamous type epithelium
LARYNX Laryngeal cartilages • Hyaline cartilages: • Thyroid • Cricoid • Arytenoid • Elastic cartilages: • Epiglottis • Cuneiform, corniculate
Epiglottis • Lingual surface • Stratified squamous epith. • Laryngeal surface • Respiratory epith. • Mixed mucous and serous glands
2 Pairs of Mucous Folds • The upper pair: • False vocal cords: (vestibular folds) • The lower pair: • True vocal cords: • Vocal ligament (elastic fiber) • Stratified squoamous epith.
TRACHEA • Respiratory epith. • C-shape rings of hyaline cartilage(pars. cartilaginea) • Pars membranacea: • Fibroelastic ligament • Smooth muscle • Mixed mucous-serous glands
Bronchial tree • Bronchi extra pulmonal • Bronchi intra pulmonal • Bronchioli (terminal bronchioles)
Bronchi • Folded appearance of the bronchial mucous (observed in histologic section) • Respiratory epith. • Mucous and serous gland • Spirally arranged smooth muscle • Rings / isolated plate of hyaline cartilage
Bronchiole • Diameter of 5 mm/less • Ciliated pseudostratified columnar ciliated simply columnar / cuboidal epith. • Smooth muscle + elastic fiber in the lamina propria • Have neither cartilage nor glands in their mucous layer
BronchialeAsthma • The musculatur (both the bronchi and the bronchioles) is under the control of the vagus nerve and the sympathetic N.S. Stimulation of • The vagus contraction • The parasympathetic relaxation
Asthma Attacks • Dispnoe (increased airway resistance) • Wheezing sounds • Decreases the diameter of the lumen • Hypersecretion of the mucous / serous glands + goblet cells
Respiratory Bronchioles • Respiratory portion • Their walls numerous saccular alveoli • Ciliated cuboidal epith. • Smooth muscle + elastic C.T.
Alveolar Ducts • Squamous alveolar cells • Smooth muscle cells • Matrix of elastic and collagen Atria Alveolar sac.
ALVEOLI • Terminal portions of the bronchial tree • Inter alveolar septum: • Capillaries • Fibroblast • Elastic and collagen fibers • Macrophages • Blood: • Air barrier • Cytoplasm of the alveolar cells • Fused basal laminae • Cytoplasm of the endothelial (continuos type)
2 TYPE OF ALVEOLAR CELLS Type I cells (squamous alveolar/ Pneumocyte type I) Type II cells (Septal cells/ Pneumocyte type II) • • Thin/squamous • Permeable to gases • • Cuboidal • Vesicular cytoplasm • Secretory cells • Pulmonary surfactant (to lower alveolar surface tension)
ALVEOLAR PORES • 10-15 m in diameter • Connecting neighboring alveoli • Equalize pressure in the alveoli • Enable the collateral circulation
PLEURA • Serous membrane covering the lung • Parietal and visceral layer • Mesothelial cells • Connective tissue (collagen + elastic) • Pleural cavity + lubricant • Pleuricy • Pneumothorax • Pleural effusion / haemothorax
DEFENSE MECHANISM • Vibrissae (screen) • Mucous-coated ciliated epith. (traped) • Cough reflex (expectoration) • Alveolar macrophages • Lymphoid tissues