tau phosphorylation n.
Download
Skip this Video
Loading SlideShow in 5 Seconds..
Tau-phosphorylation PowerPoint Presentation
Download Presentation
Tau-phosphorylation

Loading in 2 Seconds...

play fullscreen
1 / 9

Tau-phosphorylation - PowerPoint PPT Presentation


  • 2 Views
  • Uploaded on

Tau-phosphorylation from Creative Diagnostics.

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'Tau-phosphorylation' - thomasm2014


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
tau protein function
Tau protein function
  • Regulate microtubule polymerization
  • Promotes microtubule stabilization
tau protein function 1
Tau protein function
  • Regulation of axonal diameter and growth
  • Regulation of vesicle and organelle transport
  • Modulation of signaling cascades by acting as a protein scaffold
  • Cellular response to heat shock
  • Adult neurogenesis and the establishment of neuronal polarity in development

Lipids

Signaling

Molecules

Cytoskeletal

Elements

tau protein structure
Tau protein structure

Proline-rich

region

Repeats

Acidic region

R1

R3

R4

R2

C

N

  • E10
  • E10
  • E10

E3

E2

C

N

17q21

MAPT locus

E2

C

N

C

N

E2

E3

C

N

E2

C

N

phosphorylation sites
Phosphorylation sites
  • 28: exclusively phosphorylated in AD brains
  • 16: phosphorylated both in AD and in control brains
  • 31: phosphorylated in physiological conditions
  • 10: putative phosphorylation

Serine

Threonine

Tyrosine

tau hyperphosphorylation aggregation
Tau Hyperphosphorylation & Aggregation

Tau

oligomerization

NFTs

NFT

formation

Tau

aggregation

Tau cleavage &

hyperphosphorylation

P

P

P

P

P

P

P

PHF

www creative diagnostics com

www.creative-diagnostics.com

Tau Phosphorylation

45-1 Ramsey Road, Shirley, NY 11967, USA

info@creative-diagnostics.com