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protein phosphorylation

Protein Phosphorylation

e7d195523061f1c02e66e4f24090f95771f2a25398b4c6a397210DEF3B34B42E7CAE3753A3E55670C5C5B393DCCD8D49F265F3A29442F2D10D421F974AABEA3384308323DA72972389F1817D14B0E600B5EC5FA4DF8D17615469776E2EE1F7BDA4F2D725BE18C48C2354C64EE3428D3C82B58D311000F2EAAEF5551A3CF9783D6373E0A098E5A01B

www creative diagnostic com

WWW.CREATIVE-DIAGNOSTIC.COM

Phosphorylation

e7d195523061f1c02e66e4f24090f95771f2a25398b4c6a397210DEF3B34B42E7CAE3753A3E55670C5C5B393DCCD8D49F265F3A29442F2D10D421F974AABEA3384308323DA72972389F1817D14B0E600B5EC5FA4DF8D17615469776E2EE1F7BDA4F2D725BE18C48C2354C64EE3428D3C82B58D311000F2EAAEF5551A3CF9783D6373E0A098E5A01B

PO4

protein phosphorylation 1

Protein Phosphorylation

Protein Kinase

Phosphorylated

Protein

Protein

ADP

ATP

slide4

-

P

H2O

-

Phosphoprotein phosphatase

Protein-

-OH

Protein-threonine

Protein-threonine

-

Protein-serine

P

serine/threonine/tyrosine

-

Protein Kinase

ATP

ADP

protein phosphorylation is involved

Protein phosphorylation is involved in the regulation of a broad spectrum of cellular processes and states.

several signaling pathways critically involved

Several signaling pathways critically involved in the embryonic development and the modulation of gene expression are initiated from the activation of cell surface growth factor receptors that are known receptor tyrosine kinases (RTKs).

Upon ligand binding, these receptor kinases are fully activated and phosphorylate downstream, intracellular kinases to initiate phosphorylation signaling cascades.

receptor serine/threonine kinases (TGF-βR)

fibroblast growth factor receptor (FGFR)

insulin growth factor-1 receptor (IGF-1R)

receptor serine/threonine kinases (BMPR1/2)

importance of protein phosphorylation

Importance of Protein Phosphorylation

This pervasive post-translational modification (PTM) serves as molecular switch mechanism, modulating diverse protein functions including:

localization

enzymatic activity

crosstalk with other PTMs

protein turnover

interactions

conformation

protein de phosphorylation

Protein de-phosphorylation

Reversible phosphorylation of proteins during the cell cycle is a key regulatory mechanism of cytoskeleton organization, dynamics, as well as in cell differentiation and division.

do you want to know more about protein

Do you want to know more about protein phosphorylation?

Do not hesitate to contact us for any questions.

Email us at info@creative-diagnostics.com

Website: http://www.creative-diagnostics.com/

protein phosphorylation 2

Protein Phosphorylation

THANK YOU

e7d195523061f1c02e66e4f24090f95771f2a25398b4c6a397210DEF3B34B42E7CAE3753A3E55670C5C5B393DCCD8D49F265F3A29442F2D10D421F974AABEA3384308323DA72972389F1817D14B0E600B5EC5FA4DF8D17615469776E2EE1F7BDA4F2D725BE18C48C2354C64EE3428D3C82B58D311000F2EAAEF5551A3CF9783D6373E0A098E5A01B

Website: http://www.creative-diagnostics.com/

Email:info@creative-diagnostics.com

45-1 Ramsey Road, Shirley, NY 11967, USA