Protein Synthesis - PowerPoint PPT Presentation

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Protein Synthesis

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  1. Protein Synthesis Translation

  2. Translation Overview One codon One amino acid

  3. Transfer RNA

  4. Ribosomes • Peptide bond • formation • Codon-anticodon • matching

  5. T A C G G C A A A C T C C G G A C T A U G C C G U U U G A G G C C U G A A T G C C G T T T G A G G C C T G A Transcription/Translation

  6. E P A A U G G A A C C A A U G C C G U U U U A G G C C U G A Peptidyl Site Met Phe Pro Exit Site Aminoacyl Site

  7. E P A G A A G A C A U G C C G U U U U A G G C C U G A Met Pro Phe Pro

  8. Wobble • Only 45 different tRNA molecules exist • Pairing of the anticodon with the third base of the codon is less specific

  9. Protein Processing • Ribosome type depends on ultimate destination of polypeptide

  10. Protein Processing • Signal peptide region • ~ 20 peptides at start of PPChain • Binds to SRP as rest of PPChain is translated • Signal Recognition Particle • Carries whole translation complex to ER membrane • PPChain is fed into cisterna

  11. DNA Function Review • What are the three sites in a ribosome? • Spliceosome:Intron::_____:_____ • How is location of translation related to the eventual use of its product? • What is wobble?