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Laurent Pujo-Menjouet Institut Camille Jordan, Université Claude Bernard Lyon1, France PowerPoint Presentation
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Laurent Pujo-Menjouet Institut Camille Jordan, Université Claude Bernard Lyon1, France

Laurent Pujo-Menjouet Institut Camille Jordan, Université Claude Bernard Lyon1, France

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Laurent Pujo-Menjouet Institut Camille Jordan, Université Claude Bernard Lyon1, France

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  1. Modelling hematopoiesis with a multi-agent approach Application to leukemia - Introduction to the new software Workshop on population dynamics and mathematics in biology June, 16-20, 2008 – CIRM-Marseille Laurent Pujo-Menjouet Institut Camille Jordan, Université Claude Bernard Lyon1, France

  2. Samuel Bernard Julien Berro Nikolaï Bessonov Fabien Crauste Ivan Demin Olivier Gandrillon Stéphane Génieys Vitaly Volpert http://bsmc.insa-lyon.fr/~M3B/index.htm

  3. Bone Marrow

  4. Hematopoiesis Red Cells Platelets

  5. Leukopoiesis : White Blood Cell Formation

  6. Leukemia Leukemia is a malignant disease characterised by an abnormal and excessive proliferation of white blood cell precursors, blockedin a differentiation rate, and invading the whole bone marrow. Then a medullar insufficiency settles down because of a lack of red blood cells (source of anemia), normal white blood cells, mainly polynuclear (leukoneutropenia, source of serious infections) and platelets (thrombopenia, source of hemorrage provoked or spontaneous). Character : acute ou chronic Type :myeloid, lymphoid, or monocytic Chronic Myelogenous Leukemia (CML) is one of the most common type of leukemia

  7. Serial blood account and the corresponding Lomb periodogramPascal Fortin and Michael C. Mackey in “Periodic chronic myelogenous leukaemia : spectral analysis of blood cell counts and aetilogical implications” (Brit. Journal of haematology, 1999, 104, 336-345)

  8. Cell proliferation software

  9. Old Version

  10. New version of the software – an insight

  11. An Example – Modelling Hematopoiesis and a Case of Stress Erythropoiesis in the Bone Marrow Some data: Blood: 55% Plasma – 45 % Blood cells Within the 45%: 99% are RED BLOOD CELLS – Size decreases with maturity (from 14-19 µm for blasts to 7-8 µm for reticulocytes) 0.2-04% are WHITE CELLS and LYMPOCYTES Size decreases too as the red blood cells with a size of more mature cells slightly larger than for RBC) 0.6-08% are PLATELETS Size INCREASES with maturity (order of 50 to 150 µm for the Megacaryocytes)

  12. Blood Lines by Donald Metcalf - http://www.bloodlines.stemcells.com/img/Metcalf_Fig3_2.gif