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What are we learning from wildlife about endocrine disruption that is relevant to human health? . Dr. Peter L. deFur Center for Environmental Studies Virginia Commonwealth Univ June 20 2013. In A Word. Everything Well… Almost everything Considering all “not people” animals.

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what are we learning from wildlife about endocrine disruption that is relevant to human health

What are we learning from wildlife about endocrine disruption that is relevant to human health?

Dr. Peter L. deFur

Center for Environmental Studies

Virginia Commonwealth Univ

June 20 2013

in a word
In A Word

Everything

Well…

Almost everything

Considering all “not people” animals

slide3

Pesticide companies have disrupted insect hormone systems for ca. 40 years

All good science is a story – of inquiry and discovery

Hormonal control of metamorphosis in insects is affected by molting (ecdysone) and juvenile hormones

slide4

Ecdysone

Tebufenozide

Insect Juvenile Hormone

slide7

The Story continues- pick up to the early 1990’s

Beginning with wildlife in recent years

Two clutches of eggs in one nest

Cross-billed cormorant

In 1993-6

slide8

Model of how EDC acts on hormone-receptor interactions

EDC

hormone

hormone

EDC

EDC

R

R

R

Mimic normal action Abnormal action Blocked action

R= hormone receptor; EDC = endocrine disrupting chemical

fish sex change
Fish sex change

First reported in Florida in 1970’s

Male Goby fish showed female characteristics

Downstream from pulp mill effluent

Sitosterol was active chemical from trees

Reported in other rivers with pulp effluent

Resurfaced in England in 1995- thanks to John Sumpter

slide11

“steroid” mechanism of action

How does a system work?

Second messenger mechanism

lessons thus far
Lessons thus far
  • Can synthesize hormones and mimics
  • Untimely exposures can harm
  • Endogenous hormones when exogenous—
  • Mechanisms and processes
  • Low levels can harm
slide14

Ecy receptor

RxR receptor

slide15

17B-Estradiol 20- hydroxyecdysone Diethylstilbestrol (DES)

DDT Coumestrol

slide16

17 B estradiol

4-nonylphenol

Ah receptor model

BPA

chlordecone

Tributyltin

lessons learned some too late
Lessons learned- some too late
  • Biology is conserved
  • What can go wrong
  • How disruption occurs
  • New end points
  • New mechanisms
  • Indicators- the canary in the coal mine
  • Need confirmation from mammalian data
slide20

?

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