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DMSO and LY294002 Influence Akt Signaling: PP2 Dose-Response Study in OCUM-2M Cells

This study explores the effects of DMSO and LY294002 on Akt signaling in OCUM-2M cells, with a focus on the dose-response relationship of PP2. The results shed light on the modulation of Akt activity in the presence of these compounds.

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DMSO and LY294002 Influence Akt Signaling: PP2 Dose-Response Study in OCUM-2M Cells

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  1. Control (DMSO) LY294002 (20 M) Supplementary figure 1

  2. B A OCUM -2M OCUM - 2MD3 OCUM-2M OCUM-2MD3 0 5 0 5 min p85 P-Akt Actin Akt Supplementary figure 2

  3. B A : Control : PP2 0.5M 4 : PP2 2M : PP2 5M 50 : PP2 10M 3 40 * * * 30 %binding 2 20 10 1 0 1 5 25 (M) Control PP2 12 48 72 (hour) 24 Supplementary figure 3

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