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Gene Expression Profiles in PL2+ AML Cells Transduced with MIG-PL2 and MAG Vectors

Supplementary Figure 1A illustrates the gene expression profiles of cells positively transduced with the MIG-PL2 vector, including PLAGL2 and HPs, compared to those transduced with the MIG vector and sorted based on GFP expression. The analysis highlights the common deregulation of genes in PL2+ AML cells, including CBFb-MYH11+ AML blasts. The results shed light on the molecular characteristics associated with PL2+ status in acute myeloid leukemia, contributing to our understanding of the underlying biology and potential therapeutic targets.

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Gene Expression Profiles in PL2+ AML Cells Transduced with MIG-PL2 and MAG Vectors

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  1. Supplementary Figure 1 A. MIG (pMSCV-ires-GFP) I GFP LTR LTR MIG-PL2 (pMSCV-PLAGL2-ires-GFP) PL2 GFP LTR LTR I B. CBFb-MYH11 + HPs GFP sort Gene expression profile Genes commonly deregulated in PL2+ cells MIG-PL2 transduction MIG transduction GFP sort Gene expression profile Gene expression profile PL2+ AML CBFb-MYH11+ AML blasts Gene expression profile PL2- AML

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