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BlendAlyser - Turnkey system for online monitoring of blending processes. Table of content. Introduction Definition „Blending process“ BlendAlyser - Process monitoring BlendAlyser - Design and technical specification . 1. Analytical Measuring Optics. application specific measurement systems.
BlendAlyser - Turnkey system for online monitoring of blending processes
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optical measuring systems
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BlendAlyser - latest development for contact-free online monitoring of powder blending processes.
This instrument is well tailored for the needs of pharmaceutical industries
and research establishments.
Definition: Blending (process engineering):
Main aim of the blending process is the production of a blend whose sample reflects exactly, or at least by pre-defined accuracy, the ratio of the added base materials.
Pharmaceutical industry – solid blend of agent (API) and several additives (up to 10)
Tablet production which requires identical ingredients and homogenous distribution of the active pharmaceutical ingredient (API) as well as additives.
Blending and Granulation
Active Pharmaceutical Ingredient
Measurement window to which the BlendAlyser is mounted
Sampling at the blender offline lab analysis of material mixture (e.g. by HPLC)
Online process monitoring enabling the moving blender is no longer necessary, online blend analysis, immediate results
Connection via 4“ standard flange using a flange fastener
The measuring instrument is directly mounted to the blender. Measurement is performed online.
Absorbance in AU
Beginning of the blend process
Online monitoring of end point detections via NIR spectra
Wavelength in nm
Previous blending time
End point detection via Moving Block Standard Deviation I of absorbance at selected wavelength ranges
End point detection by absorbance determination at signification peaks
Addition of magnesium stearate in order to improve miscibility
End point detection by measuring API’s concentration variations – determination of chemometric calibration
till addition of magnesium stearate
after addition of magnesium stearate
Compact IP65 stainless steel housing with
Weight: 6.5 kg / 14.3 lb
Dimensions: 230 x 210 x 150 mm / 9 x 8.5 x 6 inch
Setup of Tunable Laser Systems
WARM® design - Wavelength and Amplitude Reference Module
Flat anodized aluminium heat sink for GmP
compliance, IP65 stainless steel housing
Status LED with control function:
Battery slot for easy replacement
(internal battery charger)
Power supply by slit rings
Modular process interface, can be customised to fulfil specific implementation needs standard: 4“ hygienic clamp, 18mm working distance
Installation on lab and process blenders!
Service plug for direct connection to
- keyboard / mouse
Fewest service needs due to