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Amino Acid Metabolism. بيوشيمي عمومي گروه علوم دامي دانشکده کشاورزي دانشگاه ياسوج دکتر مختار خواجوی. Role of Amino Acids. Protein monomeric units Energy source Precursors of other biological molecules. In Mammals. Plants and bacteria can produce all of them. Amino acids are precursors.

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amino acid metabolism

Amino Acid Metabolism

بيوشيمي عمومي

گروه علوم دامي دانشکده کشاورزي دانشگاه ياسوج

دکتر مختار خواجوی

role of amino acids
Role of Amino Acids
  • Protein monomeric units
  • Energy source
  • Precursors of other biological molecules
slide3

In Mammals

Plants and bacteria can produce all of them

slide8

Biosynthesis of Amino Acids

The nitrogen cycle

slide9

Biosynthesis of Amino Acids

Nitrogen Fixation -> Microorganism

slide10

Ammonium Ion Is Assimilated into Amino Acids Through Glutamate and Glutamine

Major Ammonium ion carrier

slide12

Biosynthesis of Amino Acids in Bacteria and Plants

Essential ones are in bold letters

biosynthesis of amino acids transaminations
Biosynthesis of Amino Acids: Transaminations

Amino Acid1 + a-Keto Acid2 Amino Acid2 + a-Keto Acid1

+

Glutamate

Pyridoxal phosphate (PLP)-

Dependent Aminotransferase

+

a-Ketoglutarate

products of amino acid breakdown
Glucogenic

Pyruvate

– a-Ketoglutarate

Succinyl-CoA

Fumarate

Oxaloacetate

Ketogenic

Acetyl-CoA

Acetoacetate

Products of Amino Acid Breakdown
slide16

Animals cannot carryout net synthesis of precursors of gluconeogenesis from acetyl-CoA or acetoacetate

slide20

Fate of the C-Skeleton of Amino Acids

Aromatic amino acids need oxygenases + O2

classification of organisms nitrogen excretion patterns
Classification of Organisms(Nitrogen Excretion Patterns)
  • Ammonotelic: ammonia excreting
  • Ureotelic: urea excreting
  • Uricotelic: uric acid excreting
carbamyl phosphate synthetase cps
Carbamyl Phosphate Synthetase (CPS)
  • CPSI (Mitochondria)
    • Uses NH3
    • Urea Cycle
  • CPSII (Cytosol)
    • Uses Glutamine
    • Pyrimidine Biosynthesis
slide30

Citrulline Carrier

(Ornithine Antiport)