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Bone….a dynamic organ. Functions: Protection, shape, movement, sound Blood production in marrow Storage of minerals, growth factors, fat, metals 206 bones in man…calcium hydroxylapatite composition…containing osteoblasts and osteoclasts which modulate bone

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bone a dynamic organ

Bone….a dynamic organ

Functions:

Protection, shape, movement, sound

Blood production in marrow

Storage of minerals, growth factors, fat, metals

206 bones in man…calcium hydroxylapatite composition…containing osteoblasts and osteoclasts which modulate bone

Diseases relate to minerals, D, hormones, drugs, weightlessness, etc.

Are there stem cells in bone?

a bit of background
A bit of background
  • . Albright, F.; Butler, A. M.; Hampton, A. O.; Smith, P. 1937. Syndrome characterized by osteitis fibrosa disseminata, areas of pigmentation and endocrine dysfunction, with precocious puberty in females: report of five cases. New Eng. J. Med. 216: 727-746
  • expanded clinical-pathologic scope
  • aberrant Gs a coupling to adenyl cyclase resulting in cAMP overproduction
  • ^ Michienzi,S, Cherman, Holmbeck, Funari,Collins, Bianco, Robey 2007. GNAS transcripts in skeletal progenitors. Human Mol. Genet 16: 1921-1930.