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Understanding Bone: Structure, Functions, and Related Diseases

Bone is a dynamic organ with vital functions including protection, shape, movement, blood production, and mineral storage. Comprising 206 bones in the human body, with a composition of calcium hydroxylapatite, bones contain osteoblasts and osteoclasts that modulate their health. Disorders related to minerals, hormones, drugs, and weightlessness can affect bone integrity. Research, such as the work of Albright et al. (1937) and Michienzi et al. (2007), expands our understanding of skeletal health and the role of stem cells in bones.

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Understanding Bone: Structure, Functions, and Related Diseases

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  1. Bone….a dynamic organ Functions: Protection, shape, movement, sound Blood production in marrow Storage of minerals, growth factors, fat, metals 206 bones in man…calcium hydroxylapatite composition…containing osteoblasts and osteoclasts which modulate bone Diseases relate to minerals, D, hormones, drugs, weightlessness, etc. Are there stem cells in bone?

  2. A bit of background • . Albright, F.; Butler, A. M.; Hampton, A. O.; Smith, P. 1937. Syndrome characterized by osteitis fibrosa disseminata, areas of pigmentation and endocrine dysfunction, with precocious puberty in females: report of five cases. New Eng. J. Med. 216: 727-746 • expanded clinical-pathologic scope • aberrant Gs a coupling to adenyl cyclase resulting in cAMP overproduction • ^ Michienzi,S, Cherman, Holmbeck, Funari,Collins, Bianco, Robey 2007. GNAS transcripts in skeletal progenitors. Human Mol. Genet 16: 1921-1930.

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