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Cell Signaling

Cell Signaling. Tidbit Overview. Course: Introductory Cell Molecular Biology. Unit title: Cell Signaling – The Original Social Networking. Class enrollment: 25 – 250 freshman or sophomore Student experience: Near the end of the term. Within the signal transduction unit

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Cell Signaling

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  1. Cell Signaling

  2. Tidbit Overview Course: Introductory Cell Molecular Biology. Unit title: Cell Signaling – The Original Social Networking. Class enrollment: 25 – 250 freshman or sophomore Student experience: Near the end of the term. Within the signal transduction unit Homework and pre-class assessment to encourage participation: Review cell signaling (notes and previous class content) and turn in written responses to LOC/HOC questions.

  3. Sensing the Rainbow: Demonstration of signal detection and transduction • Nose pinched • Chew skittle • Let go of nose • What happens?

  4. Sensing the Rainbow: Demonstration of signal detection and transduction • Nose pinched • Chew skittle • Let go of nose • What happens?

  5. Olfaction detection is based on GPCRs -

  6. Activity and Outcomes • Activity: Dramatize a signal transduction pathway • Outcome: The students will be able to model a hypothetical signal transduction pathway to elicit a specific cellular response

  7. What we want you to know and do • Evaluate the G protein coupled receptor pathway • Identify key components of cell signaling pathways • Design a skit to illustrate the mechanics of the pathway • Predict how the pathway would change under different conditions

  8. Timing of Tidbit Min Activity 0-2: Introduction and demonstration 2-7: In your NASI group evaluate your returned homework (total 8 groups) 7-21: Two groups merge, to plan performance (total 4 groups) 21-26: Combine 2 planning groups; perform/critique (total 2 groups)

  9. 5 Min: • In your NASI groups look at your returned homework handout. • Evaluate this piece of work using the following rubric:

  10. 13 Min: • Two groups merge (now 4 groups in total) • Create dramatization to illustrate pathway • Suggestion – divide the group into performers and a director

  11. 5 Min: Dramatime! Again pair with another group Within pair, one group performs, the other critiques (using Rubric provided) the performance

  12. Wild Card 1Beta blocker – examples Inderal or Lopressor • Blocks the binding site for epinephrine on the beta-receptor • What is the effect on your signaling pathway?

  13. Wild Card 2: Caffeine Inhibits the phosphodiesterase that breaks down cAMP. How does this affect your signaling pathway?

  14. Wild Card 3 - Anthrax One toxin in Anthrax (EF) - Increases cAMP levels Another (LF) triggers the degradation of the kinase further downstream

  15. Student Outcomes • Were you able to evaluate and construct a complete signaling pathway based on other students’ homework? • Were you able to create an accurate skit that showed you learned the pathway? • Did you see how altering the pathway affected signal transduction? • Did acting out this cellular process deepen your understanding of cell biology?

  16. Professor Outcomes • Did the students achieve the learning objective? • Modeling a hypothetical signal transduction pathway that elicited a cellular response? • Make notes in Teacher Diary of the successes and problems with executing the activity.

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