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Beneficiary 1 : Istituto di Ricerche Farmacologiche Mario Negri

Beneficiary 1 : Istituto di Ricerche Farmacologiche Mario Negri Beneficiary 2 : Istituto Superiore di Sanità Beneficiary 3 : Federazione Nazionale dell’Industria Chimica Beneficiary 4 : Politecnico di Milano, Dipartimento di Elettronica e Informazione

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Beneficiary 1 : Istituto di Ricerche Farmacologiche Mario Negri

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  1. Beneficiary 1 : Istituto di Ricerche Farmacologiche Mario Negri Beneficiary 2 : Istituto Superiore di Sanità Beneficiary 3 : Federazione Nazionale dell’Industria Chimica Beneficiary 4 : Politecnico di Milano, Dipartimento di Elettronica e Informazione Beneficiary 5 :KnowledgeMiner Software Frank Lemke

  2. Promotion of non testingmethods (NTM) fortheiruse in the REACH contextlinkingscientists, regulators and industries toevaluate and validateexisting NTM fortheirapplicationaccordingto REACH needs

  3. REACHpromotesInnovation(Article 1) REACH &INNOVATION AllInfo should be used QSAR ismentioned

  4. QSAR (Q)SAR = (Quantitative) Structure-Activity Relationship IN SILICO = f ( )

  5. Survey of current methods for the compliance to the REACH legislation Identification of the criteria for the non-testing methods for the REACH legislation Identification of suitable experimental databases/data sets for the ecotoxicological, toxicological and environmental endpoints for REACH List of (Q)SAR models for the ecotoxicological, toxicological and environmental endpoints for REACH, and their review Validation of non-testing methods (incl. read-across) Identification of boundaries for best use of models (applicability domain) and of the assessment factors

  6. Architecture for integration of different non-testing methods for best performances and coverage of applicability Communication and dissemination initiatives Web portal Project management Monitoring Audit After-LIFE Communication plan

  7. LIST OF ITALIAN LABORATORIES WHICH CAN PRODUCE THE EXPERIMENTAL RESULTS REQUESTED FOR REACH Endpointsproducedfor REACH byLaboratories

  8. Carcinogenicity: Results • Global Predictions on the 1544 compounds (CPDB+Leadscope) of the seven programs examined

  9. BCF – Best Models based on R2 and Accuracy Ordered by R2

  10. CONCLUSIONS IN SELECTED CASES NON-TESTING METHODS CAN BE USED: BEST MODELS: mutagenicity, BCF; CRITICAL MODELS: daphnia, carcinogenicity; Important to consider the applicability domain; Important the correct evaluation of the results (expert); USE of more than one model preferable.

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