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of valuable contributions to health care.

Abbott Diagnostics - over. of valuable contributions to health care. Blood donations are safer than ever…. Source: Nat. Med. 2000; 6:1082-1086. 2. YESTERDAY , TODAY, AND TOMORROW. Agar gel diffusion technique (AGD) / Ouchterlony method Simple test to perform, but

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of valuable contributions to health care.

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  1. Abbott Diagnostics - over of valuable contributions to health care.

  2. Blood donations are safer than ever… Source: Nat. Med. 2000; 6:1082-1086 2

  3. YESTERDAY, TODAY,AND TOMORROW • Agar gel diffusion technique (AGD) / Ouchterlony method • Simple test to perform, but • Subjective and difficult visual reading interpretation • Very insensitive. • In 1972 Abbott developed one of the first hepatitis surface antigen test, • AUSRIA-125, beginning our history as the world leader in • hepatitis diagnostics.

  4. Accurate Diagnosis of a Changing Target has Significant Patient Impact YESTERDAY, TODAY,AND TOMORROW • Hemodialysis Patient • Patient with kidney transplant for 10 years • Due to transplant failure on dialysis on 2003 • Initial test negative, Abbott HBsAg positive • Confirmed by further serology and DNA test • HBV with changes in 6 amino acid positions: T115R, P120Q, S154L, E164V, Q181R, S210R • Avoided potential HBV transmission Sussitz S et al., Poster at 5th Int. Symposium on Molecular Diagnostics in Laboratory Medicine, Graz, June 10-12, 2004

  5. Abbott Diagnostics continues to enhance detection accuracy YESTERDAY, TODAY,AND TOMORROW The ARCHITECT HBsAg Qualitative II assay Detects the most common HBV mutants Improved Mutant detection compared to ARCHITECT HBsAg Qualitative ARCHITECT HBsAg Qualitative II 34-6817/R02 package insert

  6. HCV Core Antigen enables early routine detection YESTERDAY, TODAY,AND TOMORROW A window period of 30-70 days after exposure exists where specific antibodies to HCV antigens are not detected (1) (1) Leary et al,J. Med Virol., 78:1436-1440 (2006) Schematic representation adapted from S. Muerhoff Viral Hepatitis, 2004, Miedouge et al, J. Clinical Virol., 48 (2010) 18-21 & George Dawson Journal Medical Virology 79:S54-S58(2007) • 1.Medici et al,J. ClinVirol. 2011. • 2.Miedouge et al J. Clin Viral., 2010;48:18-21. • 3.Mederacke et al,J. Clin Viral., 2009;46:210-215. • 4.Moscato et al, lntervirology 2011;54:61-65. • 5.Gerlich and Vockel,GHI Dec 2009.

  7. YESTERDAY, TODAY,AND TOMORROW

  8. YESTERDAY, TODAY,AND TOMORROW • Our continued innovation to support you in achieving cost-effective, timely, and reliable clinical laboratory results to impact both • individual patient management • the overall health care system

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