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Two Major Factors And Prevention Methods For Gastric Cancer Huateng

The largest genome-wide association study (GWAS) of gastric cancer in the Chinese population shows that genetic risk and lifestyle are the two major factors leading to the high incidence of gastric cancer in Chinese people.

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Two Major Factors And Prevention Methods For Gastric Cancer Huateng

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  1. Huateng Pharma https://en.huatengsci.com Two Major Factors And Prevention Methods For Gastric Cancer Gastric cancer, also known as stomach cancer, is a cancer that develops from the lining of the stomach. Most cases of stomach cancers are gastric carcinomas, which can be divided into a number of subtypes including gastric adenocarcinomas. China is the country with the largest number of incidences and deaths from gastric cancer in the world. According to the latest global cancer data released by the World Health Organization International Agency for Research on Cancer (WHO IARC) in 2020, there are 1.089 million new cases of gastric cancer worldwide and 0.768 million deaths in 2020. There are 478,000 new cases of gastric cancer (43.9%) and 373,000 deaths from gastric cancer (48.5%) in China. China has 20 percent of the world's population, but it accounts for about half of the new cases and deaths of stomach cancer. So, what are the main reasons for the high incidence of gastric cancer in China? How to prevent it? In October 2020, researchers from Nanjing Medical University, Peking University, Fudan University and Shandong First Medical University Affiliated Tumor Hospital, etc. published a research paper titled: Genetic risk, incident gastric cancer, and healthy lifestyle: a

  2. Huateng Pharma meta-analysis of genome-wide association studies and prospective cohort study in The Lancet-Oncology. https://en.huatengsci.com The largest genome-wide association study (GWAS) of gastric cancer in the Chinese population shows that genetic risk and lifestyle are the two major factors leading to the high incidence of gastric cancer in Chinese people. More importantly, a good lifestyle (no smoking, no drinking, eating less pickled food, eating more fresh fruits and vegetables) can significantly reduce the risk of gastric cancer in people with a high genetic risk of gastric cancer, which also reminds us a good lifestyle and genetic screening of gastric cancer can effectively prevent and treat gastric cancer. Genetic variation and lifestyle are related to the risk of gastric cancer, but the extent to which a healthy lifestyle can offset the genetic risk of gastric cancer is still unknown. Therefore, the research team hopes to evaluate the benefits of a healthy lifestyle for individuals with high genetic risk by establishing a genetic risk model for gastric cancer. In this meta-analysis and prospective cohort study, the research team first conducted a case-control study design in six independent GWAS, and performed a fixed-effect meta-analysis of the association between genetic variation and gastric cancer. The meta-analysis data covers 21168 individuals of Han nationality, including 10254 patients with gastric cancer and 10914 cancer-free controls. The research team identified 764 genetic variants that are significantly related to gastric cancer risk from about 7 million genetic variants, and constructed 5 gastric cancer polygenic risk scores with different significance thresholds (539 SNP, 112 SNP, and 38 SNP, 18 SNP, 12 SNP). Then, the research team compared these analysis data with the China Kadoorie Biobank (CKB), which is an independent, nationwide, and prospective cohort study. Through a prospective follow-up of 100,220 people for more than 10 years, the effectiveness of the polygenic risk score and the impact of a healthy lifestyle on the risk of gastric cancer were evaluated. A healthy lifestyle includes four points: no smoking, no drinking alcohol, eating less pickled foods, eating more fresh fruits and vegetables. Achieving these 4 points is considered as a good lifestyle, those who achieve 2-3 points are considered as an ordinary lifestyle, and those who can only achieve 1 point or none are considered as poor lifestyles. The analysis results showed that the five types of gastric cancer polygenic risk scores established by meta-analysis were significantly related to the risk of gastric cancer, and the polygenic risk score model of 112 SNP was most significantly associated with the risk of gastric cancer.

  3. Huateng Pharma Genetic risk and gastric cancer risk https://en.huatengsci.com For genetic risk, those with moderate genetic risk had a 54% increased risk of developing gastric cancer, compared with those with the lowest genetic risk in 20%. Those with the highest genetic risk of stomach cancer had a 108% increased risk. That is to say, the higher the genetic risk of gastric cancer, the higher the risk of gastric cancer. Lifestyle and gastric cancer risk In terms of living habits, compared with people with healthy lifestyles, people with an average lifestyle have a 34% increase in gastric cancer risk, while people with a poor lifestyle have a 103% increase in gastric cancer risk. In other words, as the degree of poor lifestyle increases, the risk of gastric cancer also increases.

  4. Huateng Pharma https://en.huatengsci.com The benefits of sticking to a healthy lifestyle The study also found that even with a high genetic risk of gastric cancer, if you can stick to a healthy lifestyle, that is, no smoking, no drinking, eating less pickled foods, and eating more fresh fruits & vegetables, the risk of gastric cancer will be reduced by 47%. For people with low, medium, and high genetic risk of gastric cancer, if they adhere to a healthy lifestyle, the 10-year absolute risk of gastric cancer is reduced respectively by 0.82%, 0.94%, and 1.12%. How to prevent gastric cancer This largest GWAS of gastric cancer for the Chinese population shows that genetic factors and lifestyle factors are two major factors that are independently related to the risk of gastric cancer. The study clearly shows that people with high genetic risk of gastric cancer have a higher incidence, and people with poor lifestyles also increase the incidence of gastric cancer. For those with high genetic risk, adhering to a good lifestyle can significantly offset their risk of gastric cancer. This also reminds us that sticking to a good lifestyle can prevent gastric cancer, and those people with a high genetic risk of gastric cancer should be screened in time for early detection, which can greatly increase the therapeutic effect of gastric cancer and prolong survival.

  5. Huateng Pharma As a reliable pharmaceutical intermediates supplier, Huateng Pharma is able to provide varieties of pharmaceutical intermediates. We are supply intermediates of Ilaprazole, Lansoprazole and Tegoprazan which are used for the treatment of gastrointestinal diseases. We have our own industrial park of 34,000 square meters that has been completed and put into operation since 2020 to support multi tons production. https://en.huatengsci.com Reference: Genetic risk, incident gastric cancer, and healthy lifestyle: a meta-analysis of genome-wide association studies and prospective cohort study

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