Cell Injury and the Pathogenesis of Human Disease
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Cell Injury and the Pathogenesis of Human Disease (PATH 6226). May 2 and 4, 2011 Paul Boor M.D. “Cellular basis of disease” 200 years of observation : organ and microscopic. SUGGESTED READING (PATHOLOGIC BASIS OF DISEASE, 8 th EDITION)

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Cell Injury and the Pathogenesis of Human Disease(PATH 6226)

May 2 and 4, 2011 Paul Boor M.D.

“Cellular basis of disease”

200 years of observation: organ and microscopic


SUGGESTED READING(PATHOLOGIC BASIS OF DISEASE, 8th EDITION)

CHAPTER 1Cellular Response to Stress and Toxic Insult; Adaptation, Injury, Death (pp 3-42)

CHAPTER 3Tissue Renewal, Repair, and Regeneration (pp 79-110)


Rudolph virchow 1821 1902 cell theory social medicine
Rudolph Virchow (1821-1902)Cell Theory“Social Medicine”


Cell injury general considerations
Cell Injury – General Considerations

  • Numerous causes

  • Biochemical events precede structural

  • Duration and intensity of exposure important (direct dose/response relationship)

  • Injury may be TISSUE (or cell) specific

  • Injury depends of ability of cells to respond, resist, and repair injury


Cell injury causes
Cell Injury – Causes

  • Hypoxia / Ischemia

  • Physical (mechanical, heat, radiation)

  • Chemical

  • Biologic Agents

  • Immunologic (host) reaction

  • Genetic derangement

  • Nutritional imbalance, deficiency


Cellular degeneration

Cellular Degeneration

Sublethal, usually reversible forms of cellular injury unassociated with severe cellular dysfunction.




Types of necrosis
Types of Necrosis

  • Coagulation

  • Liquefactive

  • Caseous

  • “Fat” necrosis





Key words week 1 bbsc 6626
Key Words(Week 1 BBSC 6626)

  • Anatomy of the hepatic lobule;

  • Cell: Hepatocyte, Kupffer cell, bile ductules;

  • Acetaminophen;

  • Cytochrome p450s; imines;

  • Reactive oxygen species; reactive nitrogen species; peroxynitrite;

  • Adducts