Gram Negative Sepsis: Does Double Coverage Show Mortality Benefit Preloader

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Why Double Coverage?. SynergyBroaden CoveragePrevent Resistance. Synergy. Definition: increased rate of killing when anti-microbials are combinedCriteria: MIC\'s of the 2 agents decrease by four-fold when combined (stringent but accepted)Methods to determine synergy are time-kill curves and c

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