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Immunopathology. Normal hematopoiesis Immunity vs Inflammation Examples of hypersensitivity types I - IV Autoimmune diseases Graves disease Systemic lupus erythematosis Scleroderma Immunodeficiency (congenital & acquired).

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Presentation Transcript
immunopathology
Immunopathology
  • Normal hematopoiesis
  • Immunity vs Inflammation
  • Examples of hypersensitivity types I - IV
  • Autoimmune diseases
    • Graves disease
    • Systemic lupus erythematosis
    • Scleroderma
  • Immunodeficiency (congenital & acquired)
slide2

Bone marrow stem cells give rise to various blood cells through complex differentiation pathways.

what is immunity how is it distinguished from inflammation

What is Immunity? How is it distinguished from inflammation?

Antigenic Specificity

***Memory***

Mediated by B and T Lymphocytes

hypersensitivity reactions

Hypersensitivity Reactions

Immediate (Type I)

Cytotoxic (Type II)

Immune complex (Type III)

Delayed (Type IV)

type i hypersensitivity

Type I Hypersensitivity

Mast cells with cell surface IgE receptors degranulate and release vasoactive amines (eg histamine)

type ii hypersensitivity

Type II Hypersensitivity

Antibody-Mediated Cytotoxicity

patient with graves disease
Patient with Graves Disease
  • Hyperthyoidism
  • Exophthalmia
  • Patient has auto-antibodies to the TSH receptor
  • This qualifies as a type 2 reaction
type iii hypersensitivity

Type III Hypersensitivity

Immune Complex-Mediated Tissue Injury

systemic lupus erythematosus
Systemic Lupus Erythematosus
  • Example of type 3 hypersensitivity reaction affecting skin and internal organs
  • Systemic disease
slide22

Immune complexes identified by direct immunofluorescence in a kidney biopsy from a patient with lupus nephritis.

scleroderma
Scleroderma

Scleroderma

(Collagen Vascular Disease)

type iv hypersensitivity

Type IV Hypersensitivity

Cell-Mediated (Delayed) Hypersensitivity Reaction

immunodeficiency diseases

Immunodeficiency Diseases

Congenital

(eg selective IgA deficiency)

Acquired

(eg Human Immunodeficiency Virus)

path key words
Acquired immunodeficiency syndrome (AIDS)

Adenosine deaminase deficiency

Common variable deficiency

Congenital X-linked hypogammaglobunemia

Dermatomyositis

DiGeorge syndrome

Myasthenia gravis

Raynaud phenomenon

Scleroderma

Selective IgA deficiency

Sjogren syndrome

Systemic lupus erythematosus

Path Key Words