Immunopathology. Normal hematopoiesis Immunity vs Inflammation Examples of hypersensitivity types I - IV Autoimmune diseases Graves disease Systemic lupus erythematosis Scleroderma Immunodeficiency (congenital & acquired).
Bone marrow stem cells give rise to various blood cells through complex differentiation pathways.
Mediated by B and T Lymphocytes
Immediate (Type I)
Cytotoxic (Type II)
Immune complex (Type III)
Delayed (Type IV)
Mast cells with cell surface IgE receptors degranulate and release vasoactive amines (eg histamine)
Role of Antibody and Complement in Opsonization and Phagocytosis of a Foreign Object
Immune Complex-Mediated Tissue Injury
Immune complexes identified by direct immunofluorescence in a kidney biopsy from a patient with lupus nephritis.
(Collagen Vascular Disease)
Cell-Mediated (Delayed) Hypersensitivity Reaction
(eg selective IgA deficiency)
(eg Human Immunodeficiency Virus)