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Chosen problems of immunopathology

Chosen problems of immunopathology. The physiologic function of the immune system is to protect individuals from infectious pathogens. Innate (natural, native) immunity . . Adaptive (acquired, specific) immunity. Adaptive immunity may be: 1. cell-mediated (cellular) 2. humoral.

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Chosen problems of immunopathology

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  1. Chosen problems of immunopathology

  2. The physiologic function of the immune systemis to protect individuals from infectious pathogens.

  3. Innate (natural, native) immunity .

  4. Adaptive (acquired, specific) immunity.

  5. Adaptive immunity may be:1. cell-mediated (cellular) 2. humoral

  6. Categories of immunopathology

  7. Autoimmunity - immune response against self-antigens.Autoimmune disease.

  8. Organ-specific autoimmune diseases

  9. Systemic (generalized) autoimmune diseases

  10. Rheumatoid arthritis (RA)

  11. Rheumatoid Arthritisprevalence: 1% of the world’s populationsex: female > male (2-3:1)age: 40 - 70

  12. Rheumathoid ArthritisPathogenesis

  13. Rheumatoid ArthritisMorphological features

  14. Rheumatoid ArthritisMorphological featuresJoints

  15. Rheumatoid ArthritisMorphological featuresSkin

  16. Rheumatoid ArthritisMorphological featuresRheumatoid nodules

  17. Rheumatoid ArthritisMorphological featuresBlood Vessels

  18. Rheumatoid ArthritisMorphological featuresBlood Vessels

  19. Rheumathoid ArthritisClinical features

  20. Rheumathoid ArthritisClinical featuresNo specific laboratory tests are diagnostic!Rheumatoid factor in serum important, but not present in all patients.

  21. Rheumathoid ArthritisRadiographic features

  22. The diagnosis of RA

  23. Rheumathoid ArthritisPrognosis

  24. Juvenile Rheumathoid Arthritis

  25. Juvenile Rheumathoid ArthritisSubtypes:

  26. Juvenile Rheumathoid ArthritisPathogenesis

  27. Polyarteritis nodosa(Periarteritis nodosa)

  28. Polyarteritis nodosaPathogenesis

  29. Polyarteritis nodosaMorphological features

  30. Polyarteritis nodosaMorphological featuresAcute phase

  31. Polyarteritis nodosaMorphological features Later phase

  32. Polyarteritis nodosaAll stages of disease may coexist within the same vessel and in different vessels!

  33. Polyarteritis nodosaClinical features

  34. Polyarteritis nodosaPrognosis

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