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Tricarboxylic acid cycle (TCA Cycle) [Kreb’s cycle] [Citric acid cycle]. Is the final common oxidative pathway for carbohydrates, fats and amino acids Along with energy, cycle supplies many intermediates required for the synthesis of amino acids, glucose, heme etc
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Is the final common oxidative pathway for
carbohydrates, fats and amino acids
Along with energy, cycle supplies many intermediates required for the synthesis of amino acids, glucose, heme etc
= 6 carbon tricarboxylic acid, citrate
Cis-aconitate is a transient one with very short half-life. Immediate H2O added to it and forms Isocitrate
CO2
·Isocitrate oxalosuccinate-ketoglutatrate.
It is an oxidative decarboxylation
Oxalosuccinate is unstable so it undergoes spontaneous decarboxylation to from -KG
TCA is both catabolic and anabolic amphibolic
Steps 4, 6, 10 3 NADH
1 NADH = 3 ATP] 3 ATP x 3 = 9 ATP
Step 8 1 FADH2
1 FADH2 = 2 ATP] 2 ATP x 1 = 2 ATP
Step 7 1 GTP
1 GTP = 1 ATP 1 ATP x 1 = 1 ATP
Therefore 1 acetyl CoA gives 12 ATP
Therefore 1 acetyl CoA gives 12 ATP
Two acetyl CoA in citric acid cycle produces 24 ATP
Energetics of complete oxidation of glucose
Aerobic glycolysis 8 ATP
Oxidation of 2 pyruvate = 6 ATP
Oxidation of 2 Acetyl CoA by TCA cycle 24 ATP
Net Gain = 38 ATP
Amphibolic nature of TCA cycle
Non essential aa Aspartate Acetyl CoA
Purines , Transamination
Pyrimidines.
Oxaloacetate Citrate Acetyl CoA
Fatty acids,
steroids
Pyruvate Malate -KG
Transanimation
Succinyl COA Glutamate
Heme Non-essential a a,
purines
Succinate DH Malonate }- competitive
