Despite the benefits associated with the drug, the general populations who buy modafinil online usually have very little knowledge regarding the physiological and neuropsychological processes the drug undergoes after consumption.
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Increased globalization, which has been encouraged through the introduction of the internet, has
created a common trend among university students to buy modafinil online. Most students are doing
this in an attempt to capitalize on the cognitive benefits of the drug. Research has shown that leading
psychiatrists all over the world commonly agree upon the fact that modafinil-based drugs such as
Modalert and Modvigil - as well as armodafinil-based drugs like Waklert and Artvigil - have cognitive
Many well-reputed psychological journals report that the afore mentioned nootropics can significantly
increase short-term memory, learning, cognition, focus and wakefulness among the general population.
This makes it a very useful drug among college students looking to gain an edge over their competition.
Despite the benefits associated with the drug, the general populations who buy modafinil online usually
have very little knowledge regarding the physiological and neuropsychological processes the drug
undergoes after consumption. Therefore, this article takes a brief, yet detailed look into the
neurophysiological reasons why these nootropics stimulate wakefulness in humans.
The 2001 Neuro Report revealed through extensive testing done on rats, that the drug affects the
?eu?ot?a?s?itte? ?dopa?i?e? a?d its i?te?a?tio? ?ith ?a?y a?eas i? the ??ai?. This i??ludes the st?iatu?
–?hi?h is ?o??o?ly ?ega?ded as the ??e?a?d syste?? of the ?i?d – and is directly linked to dopamine
Furthermore, The Journal of Pharmacology and Experimental Therapeutics announced that in early
2009, a team of leading neuropsychologists and pharmacologists were able to find more detailed results
of the i?te?a?tio? the d?ug has o? ou? ??ai??s dopamine system. The results supported the notion that
the ?oot?opi? a?ts as a ?dopa?i?e ?euptake i?hi?ito??.
Essentially, modafinil blocks the dopamine transporter, preventing dopamine from re-entering an area
called the presynaptic neuron. The dopamine levels then build up to a higher concentration creating a
psycho stimulant effect.
In basic terms, a psycho stimulant effect is the result of excess dopamine build-up in the neural
synapses. This results in an individual having increased alertness, higher cognition and feeling
moderately stimulated – all of which contribute to a higher sense of wakefulness.
Although modafinil affects dopamine levels, it also tends to raise histamine levels in the hypothalamus -
according to a study published in the 2007 European Journal of
Pharmacology. The hypothalamus is directly responsible for regulating the hormones that control our
basic physiology such as; hunger, sleep, sex drive and temperature regulation.
Whenever histamines are released from the hypothalamus and into areas of the brain, alertness and
?akeful?ess is i???eased d?a?ati?ally. That?s ?hy people ?ho buy modafinil online and use it regularly
are able to stay awake for longer hours than is normal – they are elevating their histamine levels using a
Although drugs like Modalert and Modvigil tend to prevent sleep through the elevation of dopamine
and histamine levels, it has also been suggested that these nootropics decrease the production of
?elato?i?, thus i?hi?iti?g sleep. Melato?i? is the ?sleep ?ole?ule? of the hu?a? ?ody, a?d is se??eted
when humans feel tired and need to sleep.
Research has found, however, that armodafinils and modafinils decrease melatonin production by
preventing the release of Gamma-Aminobutyric Acid (GABA). GABA is, as noted in a study conducted on
rats in 1984, one of the key neurotransmitters that synthesise melatonin. Meaning that the
consumption of nootropic substances will lower GABA levels, which will in turn prevent the sleep
molecule from forming. According to this theory, one could use drugs like Modalert to not only increase
wakefulness but delay the feeling associated with sleep – by temporarily preventing melatonin from
Based o? the afo?e?e?tio?ed ?ualitati?e ?esea??h u?de?take? ?y so?e of the ?o?ld?s leadi?g
psychologists, psychiatrists, neurologists and pharmaceutical scientists, it is safe to say that the secrets
of ?odafi?il?s ?akeful p?o?oti?g p?ope?ties ha?e fi?ally ?ee? ?e?ealed to the ?o?ld. This ?ea?s that
next time you buy modafinil online and use it to fight your narcolepsy, prevent your shift work sleep-
disorder or help focus during your studies, you can rest assured knowing that there is a colossal amount
of well researched evidence backing your purchase decision.