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Formation of urea

Formation of urea

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Formation of urea

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  1. Formation of urea • One of the main reasons for the production of urine is to remove urea • Urea is produced in the liver from excess amino acids • Amino acids cannot be stored so any that cannot be used at that moment have to be dealt with • Some can be transaminated to produce a different amino acid • The rest are deaminated to produce a keto acid and ammonia • The keto acid is fed into Krebs cycle and the ammonia is converted into urea by the ornithine cycle

  2. R R NH2 C COOH + 1/2 O2 C COOH + NH3 O H Keto acid Amino acid

  3. H2O CO2 NH3 ORNITHINE

  4. H2O CO2 NH3 ORNITHINE CITRULLINE NH3 H2O ARGININE

  5. H2O CO2 NH3 ORNITHINE CITRULLINE NH3 H2O ARGININE

  6. H2O CO2 NH3 ORNITHINE CITRULLINE NH3 UREA H2O ARGININE H2O

  7. H2O CO2 NH3 ORNITHINE CITRULLINE NH3 UREA H2O ARGININE H2O The urea is transported in the blood from the liver to the kidney to be filtered out and removed from the body in the urine.

  8. To test yourself on the production of urea…………………………………….click • Use your mouse to move the labels onto the diagram. Compare your diagram with the original.

  9. This is the end of this section