1 / 20

Aquasomes ppt

INTRODUCTION<br>OBJECTIVE<br>PROPERTIES OF AQUASOMES<br>PRINCIPLE OF SELF ASSEMBLY<br>METHOD OF PREPARATION OF AQUASOMES <br>EVALUATION<br>ADVANTAGES<br>APPLICATION

snehal26
Download Presentation

Aquasomes ppt

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. AQUASOMES Presented By 1) SamadhanHowal. Pharm.D (PB) 2) Snehal Kothawale. (M.PharmPharmaceutics)

  2. AQUASOMES

  3. CONTENTS • INTRODUCTION • OBJECTIVE • PROPERTIES OF AQUASOMES • PRINCIPLE OF SELF ASSEMBLY • METHOD OF PREPARATION OF AQUASOMES • EVALUATION • ADVANTAGES • APPLICATION • REFERENCES

  4. INTRODUCTION • Aquasomes were first discovered by Nir Kossovsky. • These are nanopaticulate carrier system with three layer self assembled structure • These comprises of central solid nanocrystalline core coated with polyhydroxy oligomers onto which biochemically active molecules are adsorbed.

  5. Drug/Bioactive material Carbohydrate Coating Ceramic Coating Fig. Structure Of An Aquasome

  6. Aquasomes are also called as “Bodies Of Water”,and their water like properties protect and preserve fragile biological molecules. • Maintain confirmational integrity as well as high degree of surface exposure. • The carbohydrate stabilize nanoparticle of ceramic are known as “Aquasomes”. • Aquasomes are spherical 60-300nm particle used for drug and antigen delivery.

  7. Carbohydrate Film Ceramic Nanocrystalline core Bioactive molecules Polyhydroxy oligomeric film coating

  8. OBJECTIVE • The main objective of preparing aquasomes is to protect bio-actives. • Aquasomes carbohydrate coating prevents destruction denaturing interaction between drug and solid carriers. • Aquasomes maintain molecular confirmation and optimum pharmacological activity.

  9. Provides a platform for preserving the conformational integrity of bioactive substances. Properties ofAquasome Deliver their contents through a combination of specific targeting ,slow and sustained release. Protect the drug/antigen/protein from harsh pH condition & enzymatic degradation. They exhibit the physical properties of colloids & their MOA is controlled by their surface chemistry.

  10. Principle Of Self Assembly Governed By 3 Processes A Interaction Between charged particles Hydrogen Bonding & Dehydration Effect B Structural Stability C

  11. Method of preparation of Aquasomes 1 Preparation of core 2 Coating of core 3 Immobilization Of Drug Molecule

  12. 1. Preparation Of Core • It is mainly depends upon:- • Selection of material • Its physical chemical properties • This can be fabricated by:- • Sonication • Colloidal precipitation • For the core material ,ceramic material is widely used as they are structurally to be known. • Commonly used ceramic core tin oxide & calcium phosphate.

  13. Example:-Synthesis Of Nanocrystalline tin oxide core materialThis can be prepared by Direct current reactive 1 3 inch diameter target of highly purified tin is sputterd in 2 Highpressure gas mixture of argon & oxyen 3 The ultrafine particles form in gas phase are collected on copper tube & cooled to 70 degree kelvin with liquid nitrogen

  14. 2.Coating Of Core • The second step involves the coating by carbohydrate on the surface of ceramic core. • There are number of process to enable the carbohydrate (polyhydroxy oligomers)coating to absorb epitaxially on the surface or the nano crystalline ceramic cores. • Commonly used coating material are:- • Cellobiose • Citrate • Sucrose • trihalose

  15. Process generally entails Addition of polyhydroxy oligomer To a dispersion of core in ultra pure water Lyophilization (to promote the adsorption of carbohydrate on the surface of ceramic core Excess of carbohydrate is removed by stir cell ultrafiltration

  16. 3.Immobilization Of Drug Prepare the solution of drug with known concentration in suitable buffer • The Drug Can be loaded by partial adsorption Disperse the coated particles in it Keep the dispersion overnight at low temperature or lyophilize it

  17. Evaluation Evaluation parameter Evaluation of sugar coating Evaluation of drug loaded aquasome Evaluation of ceramic core Size & shape Structure analysis Colorimetric analysis Glass transition temperature In vitro drug release studies Zeta potential Particle morphology Drug loading efficiency

  18. ADVANTAGES • Increases therapeutic efficacy of pharmaceutically active agent. • Used for various imaging test. • Act as vaccine delivery system • Novel carrier for enzyme such as DNAses and pigment/dyes.

  19. APPLICATION • Oxygen Carrier • For immunotherapy • For oral route • Anti thrombic activity • Deliveray of poorly soluble drug • Enzyme delivery • Insulin delivery • Antigen delivery

  20. THANK YOU

More Related