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Red Blood Cell Indices

Red Blood Cell Indices. Red Blood Cell Indices. They are also called red cell absolute values or erythrocyte indices. Red blood cell indices are measurements that describe the size and oxygen- carrying protein( hemoglobin) content of red blood cells.

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Red Blood Cell Indices

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  1. Red Blood Cell Indices

  2. Red Blood Cell Indices • They are also called red cell absolute values or erythrocyte indices. • Red blood cell indices are measurements that describe the size and oxygen- carrying protein( hemoglobin) content of red blood cells. • The indices are used to help in the differential diagnosis of anemia.

  3. **The relationships between the hematocrit, the hemoglobin, and the red blood cells are converted to red blood cell indices through mathematical formulas. ** The indices include these measurements: 1- Mean corpuscular volume ( MCV). 2- Mean corpuscular hemoglobin ( MCH). 3- Mean corpuscular hemoglobin concentration ( MCHC).

  4. MCV “ Mean corpuscular volume “ ** is the average volume of the RBCs in femtoliters( fl ), or 10^-15 L. MCV = HCT(%) * 10/ RBCs count (10^-12/L ) ** Cells of normal size ( MCV is 80 – 100 fl )are called normocytic, Smaller cells are microcytic, Larger cells are macrocytic.

  5. These size catedories are used to classify anemia. • * Normocytic anemia have normal size cells and a normal MCV. • * Microcytic anemia have small cells and a decreased MCV. • * Macrocytic anemia have large cells and a increased MCV. • Example: • Hct= 45%, RBCs count= 5.0 * 10^12/L, • MCV= 45 * 10 / 5.0 = 90fl.

  6. MCH “ Mean corpuscular hemoglobin” • ** is the average weight of Hb in an RBC, expressed in the units of picograms ( pg) or • ( 10^-12g). • MCH= Hb(g/dl) * 10 / RBCs count ( 10^12/L). • ** Reference range ( 28 – 32 pg ). • ** The MCH is not generally considered in the classification of anemia.

  7. Example: • Hb= 16 g/dl. • RBCs connt= 5.0 * 10^12/L. • MCH= 16.0 * 10 / 5.0= 32.0 pg

  8. MCHC • ** is the average concentration of Hb in each individual erythrocyte. • ** The units used are gram per deciliter ( formerly referred to as a percentage ). • MCHC= Hb(g/dl) * 100 / Hct (%) • ** Reference range ( 32 – 37 g/dl ). • * Hypo chromic cells are less than 32 g/dl. • * Hyper chromic cells are greater than 37g/dl. • *Values of normo chromic cells range from 32 to 37 g/dl.

  9. Anemia: a variety of condition in which a person blood can not carry as much oxygen as it should due to a decreased number or size of red blood cells. Hypochromic: a descriptive term applied to a red blood cell with a decreased concentration of Hb. Hyperchromic: a descriptive term applied to a red blood cell with a increased concentration of Hb.

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