Understanding Small-Fibre Neuropathies: Insights from Skin Denervation Evidence

May 17, 2025

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Explore the latest research on small-fibre neuropathies, focusing on denervation in patients with SFN. This study sheds light on diagnosis, pathophysiology, and management strategies.

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Understanding Small-Fibre Neuropathies: Insights from Skin Denervation Evidence

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Figure 1Evidence of denervation in the skin of patients with SFN Hoeijmakers, J. G. et al.(2012)Small-fibre neuropathies—advances in diagnosis, pathophysiology and management Nat. Rev. Neurol.doi:10.1038/nrneurol.2012.97

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Figure 1. Flow chart of the studied patients

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Figure 1 Dorsal views of patients with neuralgic amyotrophy

Figure 1 Dorsal views of patients with neuralgic amyotrophy. van Alfen, N. (2011) Clinical and pathophysiological concepts of neuralgic amyotrophy Nat. Rev. Neurol. doi:10.1038/nrneurol.2011.62.

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Figure 1 The components of the GBM. Suh, J. H. & Miner, J. H. (2013) The glomerular basement membrane as a barrier to albumin Nat. Rev. Nephrol. doi:10.1038/nrneph.2013.109.

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Supplementary Figure 1. Flowchart of patients included in the training set.

273 fresh frozen tissue samples. 74 excluded 47 with highly degraded RNA 16 with low concentration of RNA 5 with good quality RNA, but no microarray performed, 6 without RNA extracted. 199 microarray analysis performed. 8 excluded 4 with microarray of inferior quality

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Figure 3 Algorithm showing the management of patients with small bowel adenocarcinomas

Figure 3 Algorithm showing the management of patients with small bowel adenocarcinomas. Raghav, K. & Overman, M. J. ( 2013) Small bowel adenocarcinomas—existing evidence and evolving paradigms Nat. Rev. Clin. Oncol. doi:10.1038/nrclinonc.2013.132.

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Figure 1 The repressive control of puberty

Figure 1 The repressive control of puberty. Ojeda, S. R. & Lomniczi, A. (2013) Unravelling the mystery of puberty Nat. Rev. Endocrinol. doi:10.1038/nrendo.2013.233.

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Figure 1 . Flow diagram of patients referred by hospitals.

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Figure 1 The timeline of development

Figure 1 The timeline of development. Knuesel, I. et al. (2014) Maternal immune activation and abnormal brain development across CNS disorders Nat. Rev. Neurol. doi:10.1038/nrneurol.2014.187.

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