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Simulation and Experimental Studies of Biomechanics at the Micro-Scale. Elizabeth Nettleton, Undergraduate: Chemistry, University of South Dakota IM SURE Fellow, 2006 Dr. William C. Tang, Professor and Mentor: Biomedical Engineering, University of California, Irvine

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simulation and experimental studies of biomechanics at the micro scale

Simulation and Experimental Studies of Biomechanics at the Micro-Scale

Elizabeth Nettleton, Undergraduate: Chemistry, University of South Dakota

IM SURE Fellow, 2006

Dr. William C. Tang, Professor and Mentor: Biomedical Engineering, University of California, Irvine

Gloria Yang, Graduate Student: Electrical Engineering, University of California, Irvine

outline
Outline
  • The Work of the Tang Lab
  • My Role in the Project
  • My Work
  • Results
  • Conclusion
  • Acknowledgements
the big picture my lab s goals
The Big Picture—My Lab’s Goals
  • Heart Valve
    • Prosthetic valves weaken over time
    • Use a sensor to provide measurements of strain within a valve
  • Bone Strain
    • Bone tumors and osteoporosis lead to a decrease in skeletal density
    • Monitoring bone strain could track skeletal remodeling and disease progression
device designs
Device Designs

Cantilever Beam: Heart Valve

Strain Gauge: Bone

Photos Courtesy of Gloria Yang

my role in the project
My Role in the Project
  • Heart Valve Investigation
    • Use COMSOL to find the values of the spring constant, k, and resonant frequency, ω, of our device
    • Use a probe station to characterize the device
    • Characterize the effects of adhesives on heart valves
    • Use our device to find the compliance over the surface of the heart valve tissue
my role cont
My Role, Cont.
  • Bone Investigation
    • Use COMSOL to model heat transfer of a device to surrounding tissue
  • Work Applicable to Both Projects
    • Research adhesives
      • Biocompatibility, faithful transmission of surface tension to sensor, etc
      • Ethicon: Johnson & JohnsonMicrovalBD HealthsciencesCryolife
edwards lifesciences
Edwards Lifesciences
  • Learned about prosthetics
  • Use their bovine pericardium valves
  • Use their equipment to test adhesion effects

Carpentier-Edwards PERIMOUNT Pericardial Bioprosthesis Aortic Model 2700

dermabond adhesive
Dermabond—Adhesive
  • Manufactured by Ethicon, a Johnson & Johnson Company
  • Attached sensor prototype to a foam block simulating the skin’s surface
  • In the process of monitoring adhesive properties for seven days
results
Results
  • Cantilever Modeling
    • Spring Constants
      • COMSOL vs. Theoretical Values: Percent Difference for each length <1.32%
    • Resonant Frequencies: forthcoming?
      • As of yet, our simulations have not been successful. We have no data to compare to the theoretical values.
results cont
Results, Cont.
  • Probe Station—Device Characterization
    • Multimeter vs. Wheatstone Bridge
      • Graphed resistance changes vs. probe displacement
      • Results similar for both
      • Data best when lines of best fit forced through zero
      • Multimeter-lower standard deviation
      • Repeating Wheatstone bridge measurements, changing technique
results cont1
Results, Cont.
  • Heat Transfer Modeling
    • Have the model completed, working to apply boundary conditions
  • Adhesive Testing
    • Currently monitoring Dermabond on foam block
conclusions
Conclusions
  • What I’ve achieved:
    • Providing theoretical data for the spring constant of our device
    • Characterizing the device—its changing resistance with changing deflection
  • I’ve also provided initial data on:
    • Modeling the resonant frequency of our device
    • Modeling the heat transfer in an implanted device
    • Monitoring the adhesion of Dermabond
conclusions cont
Conclusions, Cont.
  • Future Work
    • Currently the heart valve project is focused on prosthetic valves
    • Eventually, apply research to living heart valves, in vivo
      • Real-Time measurements
      • Wireless Communication System
acknowledgements
Acknowledgements
  • I would like to thank the following people and organizations for making this experience possible:
    • My mentor, William C. Tang
    • My graduate student, Gloria Yang
    • The Tang Lab, as a whole
    • UROP and the IM-SURE Program
    • National Science Foundation