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Enhancing ACT Availability: ARTEPAL Project Overview

ARTEPAL is a 3-year EU-funded project focusing on technology transfer, pregnant women, and distribution to improve the availability of ACTs. It evaluates supply chain projects, extraction processes, and quality requirements, aiming to address issues identified by WHO/RBM/MMSS and others. The proposal includes a guide for API production covering cultivation, Artemisinin production, extraction units, and market analysis.

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Enhancing ACT Availability: ARTEPAL Project Overview

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  1. THE ARTEPAL PROJECT TO IMPROVE THE AVAILIBILITY OF ACT Nairobi03/2006

  2. ARTEPAL1/ THE PROJECT • PROJECT OF AEDES FOUNDATION • Agreed and financed by E.U. on 3 years • 3 sections: technology transfer, pregnant women, distribution • Oteci (senior-experts) in charge of technology transfer under control of a technical and scientific committee. • OBJECTIVE: IMPROVE AVAILIBILTY OF ACTs Nairobi03/2006

  3. ARTEPAL2/SITUATION • Evaluation of projectsin all the supply chain (plantations, extraction, pharma) and in different regions • Evaluation of extraction processes • Establishing connections between different partners • Support in GMPs at different levels in connection with WHO/pre-qualification. Nairobi03/2006

  4. ARTEPAL3/ FINDINGS • Numerous projects restarting basic studies available in the literature • Numerous plantation projects without available extraction unit. • Numerous projects without knowledge of the commercial possibilities and quality requirements • Numerous questions asked to WHO/RBM/MMSS and others Nairobi03/2006

  5. ARTEPAL3/FINDINGS • Since the meeting in Arusha, risks of inadaptation of demand and supply are increasing. • Quantities • Quality • Recommandation of WHO for only ACTs may deeply change the demand Nairobi03/2006

  6. ARTEPAL4/PROPOSAL S • WHO/RBM/MMSS with MSH/RPM Plus intend to produce a guide to API production covering : • Cultivation issues on artemisia annua: • Seeds: sourcing, quantities needed • Planting, growing conditions, climate… • Areas of cultivation and surfaces • Major issues, agricultural and financial • Average biomass and artemisini content Nairobi03/2006

  7. ARTEPAL4/PROPOSALS • Production of Artemisinin • Extraction units: • Where • Capacity, quantity and time of production • Kind pf process • Possibilities to extract other products • Constraints: technical, financial • Issues involved with respect to the quality of finished ACTs: • GAP • GMP • DMF… Nairobi03/2006

  8. ARTEPAL4/PROPOSALS • Main deliverable: • « Market analysis »of the current situation in terms of capacity, quality issues,.. • A guide for resources, contacts • Table or tool to estimate cultivation and extraction needs across the production chain. Nairobi03/2006

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