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CRC: staging and TNM classification

CRC: staging and TNM classification. CRC staging and TNM classification. Anatomic stage/prognostic groups. The most frequently used system to stage CRC is the American Joint Committee on Cancer TNM system , which is based on: 1 The size and extent of the primary tumour (T )

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CRC: staging and TNM classification

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  1. CRC: staging and TNM classification

  2. CRC staging and TNM classification Anatomic stage/prognostic groups The most frequently used system to stage CRC is the American Joint Committee on Cancer TNM system, which is based on:1 The size and extent of the primary tumour (T) Whether the cancer has spread to nearby (regional)lymph nodes (N) Whether the cancer has metastasised to other organs (M) Once the T, N and M categories have been defined, this information is combined to assign an overall stage of 0, I, II, III or IV1 This process is called stage grouping, and results in a range of anatomical stage or prognostic groups (right) The Dukes system has been used historically to stage CRC2 CRC, colorectal cancer; T1mi, minimally invasive adenocarcinoma; Tis, tumour in situ; TNM, tumour, node, metastasis. 1. Gress DM, et al (Eds). Principles of cancer staging. AJCC Cancer Staging Manual. 8th ed. New York, NY: Springer. 2017. 2. Haq AI, et al. Lancet Oncol 2009;10:1128.

  3. CRC TNM classification explained1 *There is no designation of MX. The absence of any clinical history or physical findings suggestive of metastases in a patient who has not undergone any imaging is sufficient to assign the clinical M0 category. There is no designation of pM0. Biopsy or other pathological information is required to assign the pathological M1 category. Patients with a negative biopsy of a suspected metastatic site are classified as clinical M0 (cM0). cM, clinical metastasis; Tis, tumourin situ. 1. Gress DM, et al (Eds). Principles of cancer staging. AJCC Cancer Staging Manual. 8th ed. New York, NY: Springer. 2017.

  4. International disease classification system: CRC Example ICD-O topography codes for malignant colorectal neoplasms2,3 • ICD-O codes are a subgroup of oncology-specific codes within the overarching ICD coding architecture1 • The structure of ICD-O codes indicates a tumour’s:1 • Topography: location / site within the body: • All CRC codes are denoted by the prefix C • Morphology/histology: appearance when examined under the microscope ICD-O, International Classification of Diseases for Oncology. 1. Fritz A, et al. International Classification of Diseases for Oncology 2000‎‎; 3rd ed. World Health Organization. Available at: https://apps.who.int/iris/handle/10665/42344 (Accessed September 2019).2. Colorectal Cancer Control Program. Approved ICD-10 Code List. 2019. Available at: https://www.michigancancer.org/Colorectal/PDFs/ICD10Codes/FY20CRCICD10.pdf (Accessed September 2019).3. Kuipers EJ, et al. Nat Rev Dis Primers 2015;1:150652.

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