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BLOOD ADMINISTRATION. NRS 108 ESSEC COUNTY COLLEGE Majuvy L. Sulse MSN, RN,CCRN. Objectives: Use safe accurate techniques and apply the nursing process when caring for clients who are receiving blood and blood products . Definition of terms .

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blood administration


NRS 108


Majuvy L. Sulse MSN, RN,CCRN

Objectives:Use safe accurate techniques and apply the nursing process when caring for clients who are receiving blood and blood products.
definition of terms
Definition of terms
  • Antigen-substance that elicits an immune response; mostly proteins (can also be lipoproteins, polysaccharides and nucleic acids.
  • Antibody-substances produced by the plasma (300 molecules/sec) secreted into the blood & other extracellular fluids
  • Agglutination-a clumping like antibody action that results from an antibody molecules having at least two antigen binding sites
definition of terms cont d
Definition of terms cont’d
  • Lysis-cell membrane destruction, occurs because of antibody binding to membrane- bound antigens of some invaders.
  • Blood transfusion- are actual transplantation of tissue from one person to another. Donor and recipient must be checked for compatibility to prevent lethal reactions.
blood transfusion cont d
Blood Transfusion cont’d
  • Compatibility is determined by 2 different types of antigen systems (Cell surface proteins) ABO system antigen & the Rh antigen (membrane surface of the RBCs)
  • RBC antigens are inherited and maybe one of the following: A antigen (type A blood) B antigen (type B blood) Both A & B antigen (type AB blood) No antigen (type O blood)
compatibility chart for red blood cell transfusion
Compatibility Chart for Red Blood Cell Transfusion



Donor_______A______B______ AB_____0_





rh compatibility
Rh Compatibility
  • An Rh negative person is born without the antigen and does not form antibodies unless he or she is spefically sensitized to it. Sensitization can occur with RBC transfusions from an Rh positive person or exposure during pregnancy and birth.
  • An Rh positive person can receive an RBC transfusion from an Rh negative donor
  • Rh negative people MUSTNEVER receive Rh positive blood.
blood product components indications for usage
Blood Product Components & Indications for Usage
  • Red Blood Cell (RBC)- administered to
    • replace erythrocytes lost from trauma
    • Erythrocytes lost from surgical intervention
    • clinical conditions that result in destruction or abnormal maturation of RBCs
    • Hgb less than 6 g/dL or 6-10 g/dL if clinical symptoms are present.
blood product components indications for usage cont d
Blood Product Components & Indications for Usage-cont’d
  • Platelet Transfusions are administered
    • Platelet counts below 20,000 mm3
    • Thrombocytopenic patients actively bleeding or going for an invasive procedure
blood product components indications for usage cont d1
Blood Product Components & Indications for Usage-cont’d
  • Cryoprecipitate-
    • product derived from plasma. Clotting factors (Vlll, Xlll), fibronectin, and fibrinogen are precipitated from pooled plasma.
    • Clients with fibrinogen level less than 100 mg/dL or clotting factor disorder at a volume of 10-15 ml/unit usually IV push within 3 minutes
blood components continued
Blood Components continued
  • Plasma
    • Replaces blood volume.
    • Used for clients with clotting disorders.
    • Actively bleeding with PT or PTT greater than 1.5 times than normal.
    • ABO compatibility is required for transfusion of plasma products.
    • FFP volume is about 200 cc is given as rapidly as the pt. can tolerate while the clotting factors are viable generally over a 30-60 minute period. Use a regular Y set or straight filtered tubing.

Nurses responsibilities when Initiating, Maintaining & terminating A Blood transfusion Therapy1. Assess lab values2. Verify medical order3. Send blood specimen for type & cross-matching4. Obtain blood consent from client or next of kin if unable/incompetent to sign5. Assess VS, urine output, skin color, and history of transfusion reactions

6. Obtain venous access- large bore needle g.19
  • 7.Obtain blood product from the blood bank
  • 8. With another RN, verify client’s name, & number, blood compatibility and note expiration time.
  • 9. Administer blood using appropriate filtered tubing as soon as possible
  • 10 Use only normal saline for priming the tubing or for dilution
nurses responsibilities when initiating maintaining terminating a blood transfusion therapy
Nurses responsibilities when Initiating, Maintaining & terminating A Blood transfusion Therapy
  • 11.Infuse slowly at about 2 ml/min during the 1st 15 minutes then adjust at ordered rate
  • 12.Remain with the client for the first 15-30 minutes of infusion
  • 13. Take VS and record as per facility’s policy
  • 14.Upon completion of transfusion, discontinue infusion & dispose of bag & tubing properly.
  • 15. Document.
transfusion reactions
Transfusion Reactions
  • An adverse reaction to blood transfusion therapy ranging from mild to life threatening condition. If this occurs:
      • Stop the transfusion
      • Maintain a patent IV line with Normal saline
      • Notify the healthcare provider & blood bank
      • Recheck identifying tags & numbers
      • Monitor VS and urine output
transfusion reactions1
Transfusion Reactions
  • Treat symptoms per physicians order
  • Save blood bag and tubing and send to blood bank for exam
  • Complete transfusion reaction reports
  • Collect required blood and urine specimen at intervals per hospital policy to evaluate for hemolysis
  • Document on transfusion reaction form and patient chart
acute transfusion reactions
Acute Transfusion Reactions
  • Acute Hemolytic Reaction-
      • Cause by ABO or Rh incompatibility
  • Clinical signs
      • Mild reaction with fever and chills or life threatening like DIC & circulatory collapse
      • Apprehension
      • Headache
      • Chest pain
      • low back pain
      • Tachycardia/tachypnea
      • Hypotension
      • Hemoglobinuria
acute reactions cont d
Acute Reactions cont’d.
  • Febrile Reactions
      • Caused by leukocyte incompatibility
      • Prevented by using leukocyte filter tubing
  • Clinical signs
      • Sensation of cold
      • Tachycardia
      • Fever
      • Hypotension
      • Tachypnea
acute reactions cont d1
Acute Reactions cont’d
  • Allergic reactions
      • Results from sensitivity to plasma proteins of the donor or history of allergy
      • Antihistamines ( Epinephrine/corticosteroids) are used to prevent reaction
      • Washed RBCs are given for those with history of allergy
  • Signs:
      • Urticaria
      • Itching
      • Bronchospasm or anaphylactic reactions
acute reactions cont d2
Acute Reactions cont’d
  • Circulatory overload
      • Occurs when blood product is administered too quickly
      • Cardiac or renal insufficiency and older population at risk
  • Signs:
      • Hypertension
      • Bounding pulse
      • Distended jugular veins
      • Dyspnea
      • Restlessness
      • confusion
acute reactions cont d3
Acute Reactions cont’d
  • Bacterial transfusions reactions (Sepsis)
      • Blood products infected from improper handling and storage
      • May cause bacteremia or septic shock
  • Massive transfusion reactions-due to large volume of transfusions and can cause:
      • Hypothermia
      • Cardiac arrythmias
      • Citrate toxicity
      • Hypocalcemia
      • Hyperkalemia
delayed transfusion reactions
Delayed transfusion Reactions
  • Delayed hemolytic reactions
  • Hep B
  • Hep C
  • HIV
  • Iron overload
  • Graft versus host disease